FRED Sanger is an amazingly modest man, and his into the Laboratory of Molecular Biology), took me on as a research student. Vernon had just shown that sickleown retrospective, written after he retired, a delightful prefatory chapter for the Annual Reviews of cell hemoglobin differed from normal hemoglobin by a single amino acid substitution, the first characterizaBiochemistry, is called “Seque...

Fred Sanger developed technologies that won him two Nobel Prizes and revolutionized biological research. Yet, in spite of this record, the question has been raised as to whether, in the current scientific climate, he might be unsuccessful in obtaining a grant because of a productivity that would be viewed as too limited. In imagining how a National Institutes of Health study section today might...

Abstract This paper introduces , a new semantic role labeling method that transforms text into frame-oriented knowledge graph. It performs dependency parsing, identifies the words evoke lexical frames, locates roles and fillers for each frame, runs coercion techniques, formalizes results as formal representation complies with frame semantics used in Framester, factual-linguistic linked data res...

We develop a method for constructing prediction intervals nonstationary variable, such as GDP. The uses Factor Augmented Regression (FAR) model. predictors in the model include small number of factors generated to extract most information set panel data on large macroeconomic variables that are considered be potential predictors. novelty this article is it provides and justification mixture sta...

Flow-diverting stents can help treat complex and wide-necked cerebral aneurysms. The aim of the study was to evaluate initial experiences related to the safety and effectiveness of eight aneurysms treated with a new dual layer coverage designed flow-diverter device. In 2012 Fred flow-diverter devices were used to treat 8 unruptured wide neck (dome-neck ratio ≤ 1.5) and sidewall aneurysms in 6 p...

THE production of mannitol by bacterial fermentation has been extensively studied, since the organisms concerned are a source of trouble in the wine industry. Gayon and Dubourg [1901] showed that although glucose, sorbose, galactose, mannose, sucrose, maltose, lactose, raffinose and xylose are all fermented, laevulose alone yields mannitol. They found that arabinose and trehalose are not attack...