A new numerical scheme is proposed for flow computation in complex discrete fracture networks. The method based on a three-field domain decomposition framework which independent variables are introduced at the interfaces generated process of decoupling original problem whole network into set fracture-local problems. PDE-constrained formulation then used to enforce compatibility conditions inter...

Abstract We propose a quality-based optimization strategy to reduce the total number of degrees freedom associated with discrete problem defined over polygonal tessellation Virtual Element Method. The presented Quality Agglomeration algorithm relies only on geometrical properties mesh, agglomerating groups neighboring elements. test this approach in context fractured porous media, which generat...

Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients. However, there have been no data showing actions on Japanese bone architecture. Here we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for 3 years. Compared to placebo, denosumab significantly...

Introduction: The penis fracture is a pathological condition that calls for immediate treatment. Nocturnal penile fracture has previously been described; however, the occurrence of such an event in a child is unprecedented in the current medical literature. Case presentation: In this paper, we present a case of a black child with penis fracture caused by nocturnal unconscious manipulation. The ...

INTRODUCTION: Fracture healing is a complex, well-orchestrated process, and animal models are essential to enhance our understanding of the mechanisms involved. Whereas in the past large animals like sheep and dogs were chosen for fracture healing studies, nowadays, smaller animals like mice and rats are used, especially to analyze the molecular aspects of fracture healing. Mouse models are che...

Introduction: Nature produces amazingly varied geometrical patterns. In particular, logarithmic spirals are abundantly observed in nature. Gastropods/cephalopods (such as nautilus, cowie, grove snail, thatcher, etc.) in the mollusca phylum have spiral shells, mostly exhibiting logarithmic spirals vividly. Spider webs show a similar pattern. The low-pressure area over Iceland and the Whirlpool G...