In the absence of a direct method with which to measure pulmonary capillary pressure in humans, various methods for analyzing the pulmonary artery pressure decay following balloon occlusion have been described. In this issue of Critical Care, Souza and coworkers investigate the adequacy of these methods for assessing various pathophysiological processes. They studied patients presenting with pa...

The Vestnesa Ridge, located off the west Svalbard margin, is a >60 km long ridge consisting of fine-grained sediments that host deep-marine gas hydrate and associated seepage system. Geological geophysical observations indicate predominance vertical fluid expulsion through fractures with pockmarks expressed on seafloor along entire ridge. However, despite apparent evidence for an extended fr...

An interpretive model of the myogenic autoregulatory response of cat mesenteric arterioles has appeared in the literature; it describes arteriolar dimensional changes during changes in mean systemic arterial blood pressure in terms of tension-radius diagrams (Laplace relationship). The original model assumes that arteriolar pressure is a simple, linear function of systemic blood pressure and th...

Systemic capillary leak syndrome is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. A 26-year-old woman was admitted because of recurrent episodes of hypovolemic shock. Hemoconcentration, hypoalbuminemia, and monoclonal gammopathy were observed. We diagnosed systemic capillary leak syndrome. Three years later, she again had an attack of systemi...

BACKGROUND Intracoronary physiology techniques have been validated extensively for the assessment of epicardial stenoses but not for the lone study of coronary microcirculation. We performed a comparison between 4 intracoronary physiological indices with the actual structural microcirculatory changes documented in transplanted hearts. METHODS AND RESULTS In 17 cardiac allograft patients witho...

The capillary action of saliva occurs in the crevices around and between teeth and around dental restorations. Marginal leakage and denture retention caused by a thin film of saliva are aspects of capillary phenomena. Liquids in capillaries isolated from a reservoir showed an increase in surface tension and lower vapor pressure. The strength of thin films of human saliva was independent of ambi...

Abstract In this paper, the development of a three-dimensional, two-phase fluid flow model (Modified Embedded Discrete Fracture Model) to study performances fractured horizontal well in deep-marine shale gas is presented. Deep-marine resources account for nearly 80% China, which decisive resource basis large-scale production. The dynamic characteristics deep reservoirs are quite different and m...

BACKGROUND Hemodynamic assessment after volume challenge has been proposed as a way to identify heart failure with preserved ejection fraction. However, the normal hemodynamic response to a volume challenge and how age and sex affect this relationship remain unknown. METHODS AND RESULTS Sixty healthy subjects underwent right heart catheterization to measure age- and sex-related normative resp...