نتایج جستجو برای: foxo1

تعداد نتایج: 2363  

2015
Min Zhou Yadi Zhang Xulin Chen Jianjun Zhu Min Du Liang Zhou Ling Zhang Wei Wang Gengyun Sun

PTEN is a multifunctional phosphatase that regulates immune responses through a PI3K/Akt signaling cascade. HMGB1 plays an important role in the initiation of innate immune responses to induce acute lung injury (ALI). This study was designed to investigate the role of PTEN/Foxo1 signaling in the regulation of in vivo and in vitro innate immune responses in ALI. Using a mouse model of ALI, wild-...

Journal: :Cancer research 2009
Cara J Lau Zaf Koty Josephine Nalbantoglu

Gliomas are the most common adult primary brain tumors, and the most malignant form, glioblastoma multiforme, is invariably fatal. The phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway is altered in most glioblastoma multiforme. PTEN, an important negative regulator of the PI3K-Akt pathway, is also commonly mutated in glioma, leading to constitutive activation of Akt. One ultimate cons...

2015
Shivatra Chutima Talchai Domenico Accili

β-Cell dysfunction in diabetes results from abnormalities of insulin production, secretion, and cell number. These abnormalities may partly arise from altered developmental programming of β-cells. Foxo1 is important to maintain adult β-cells, but little is known about its role in pancreatic progenitor cells as determinants of future β-cell function. We addressed this question by generating an a...

2015
Zhonglin Han Yu Jiang Yuqing Yang Xuehan Li Zhongzhou Yang Kejiang Cao Dao W. Wang

BACKGROUND The AGC protein kinase family regulates multiple cellular functions. 3-phosphoinositide-dependent protein kinase-1 (PDK1) is involved in the pathogenesis of arrhythmia, and its downstream factor, Forkhead box O1 (Foxo1), negatively regulates the expression of the cardiac sodium channel, Nav1.5. Mice are known to die suddenly after PDK1 deletion within 11 weeks, but the underlying ele...

Journal: :Science 2006
Haojie Huang Kevin M Regan Zhenkun Lou Junjie Chen Donald J Tindall

The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell cycle arrest and DNA repair. However, whether CDK2 also influences the survival of cells under genotoxic stress is unknown. Forkhead box O (FOXO) transcription factors are emerging as key regulators of cell survival. CDK2 specifically phosp...

2016
Jia-Qing Zhang Bin-Wen Gao Jing Wang Qiao-Ling Ren Jun-Feng Chen Qiang Ma Zi-Jing Zhang Bao-Song Xing

Reactive oxygen species (ROS) are closely related to the follicular granulosa cell apoptosis. Grape seed procyanidin B2 (GSPB2) has been reported to possess potent antioxidant activity. However, the GSPB2-mediated protective effects and the underlying molecular mechanisms in granulosa cell apoptosis process remain unknown. In this study, we showed for the first time that GSPB2 treatment decreas...

Journal: :The EMBO journal 2007
Keisuke Sekine Yen-Rong Chen Nobuhiko Kojima Kazuhiro Ogata Akiyoshi Fukamizu Atsushi Miyajima

C/EBPalpha is a key transcription factor indispensable for the onset of gluconeogenesis in perinatal liver. However, C/EBPalpha was already expressed in fetal liver, suggesting that the expression of C/EBPalpha alone does not account for the dramatic increase of the expression of metabolic genes, and hence an additional factor(s) is expected to function cooperatively with C/EBPalpha in perinata...

Journal: :Immunity 2010
Yann M Kerdiles Erica L Stone Daniel R Beisner Maureen A McGargill Irene L Ch'en Christian Stockmann Carol D Katayama Stephen M Hedrick

Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid cells. Here, we showed the absence of Foxo1 severely curtailed the development of Foxp3(+) regulatory T (Treg) cells and those that developed were nonfunctional in vivo. The loss of function included diminished CTLA-4 receptor expression ...

2014
Ann-Kristin Fjällström Kim Evertsson Marlene Norrby Sven Tågerud

BACKGROUND Forkhead box O (FoxO) transcription factors and E3 ubiquitin ligases such as Muscle RING finger 1 (MuRF1) are believed to participate in the regulation of skeletal muscle mass. The function of FoxO transcription factors is regulated by post-translational modifications such as phosphorylation and acetylation. In the present study FoxO1 protein expression, phosphorylation and acetylati...

Journal: :Circulation. Heart failure 2015
Yajuan Qi Qinglei Zhu Kebin Zhang Candice Thomas Yuxin Wu Rajesh Kumar Kenneth M Baker Zihui Xu Shouwen Chen Shaodong Guo

BACKGROUND Heart failure is a leading cause of morbidity and mortality in the USA and is closely associated with diabetes mellitus. The molecular link between diabetes mellitus and heart failure is incompletely understood. We recently demonstrated that insulin receptor substrates 1, 2 (IRS1, 2) are key components of insulin signaling and loss of IRS1 and IRS2 mediates insulin resistance, result...

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