This study concerns thanatochemistry, an important sub-branch of forensic toxicology dealing with uncontrolled biochemical post-mortem processes resulting in autosynthesis of endogenous chemical compounds. Knowledge of chemical structure of endogenous products formed in the course of autolysis and putrefaction is of paramount importance for diagnosis and indispensable for interpretation of typi...

No computation is performed more frequently by forensic toxicologists than that involving Widmark's equation. The equation is employed to estimate either the number of drinks consumed or the corresponding blood or breath alcohol concentration. Despite the wide use of Widmark's equation, rarely is an uncertainty estimate also provided. Estimates from Widmark's equation involve at least seven unc...

Determination of cocaine and its metabolites in biological specimens is of great importance, not only in clinical and forensic toxicology, but also in workplace drug testing. These compounds are normally screened for using sensitive immunological methods. However, screening methods are unspecific and, therefore, the posterior confirmation of presumably positive samples by a specific technique i...

The questions of whether the dose of drug that is consumed corresponds to drug concentration levels in hair and how results of hair analyses can be interpreted are still debated. The aim of this study was to investigate (1) whether there is a correlation between doses of Methamphetamine (MA) use and MA concentration levels in hair and (2) whether results of hair analyses can be used to estimate...

a high performance liquid chromatographic method with ultra violet detection for simultaneous analysis of six benzodiazepines (bzds) (chlordiazepoxide, diazepam, clonazepam, midazolam , flurazpam and lorazepam) has been developed for forensic screening of adulterated non-alcoholic drinks. samples were analyzed after a simple procedure for preparation using ph adjustment and filtering. isocratic...

Chiral substances possess a unique architecture such that, despite sharing identical molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be superimposed. Thus, in the environment of living systems, where specific structure-activity relationships may be required for effect (e.g., enzymes, receptors, transporters, and DNA), the physiochemical and biochemical properties o...

Clinical toxicology (CT) and forensic (FT) represent two disciplines of dedicated to the qualitative quantitative analysis respective interpretation alcohol, drugs abuse (DOA), over counter (OTC), prescription or poisons, mainly in humans. Analytical challenges, such as transient occurrence new psychoactive substances (NPS) on (il)legal drug market, insufficiently long detection windows some DO...