Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST). Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injec...

Objective(s): This study evaluated the effect of swimming exercise during spontaneous methamphetamine (METH) withdrawal on the anxiety, depression, obsessive-compulsive disorder (OCD) and voluntary METH consumption in METH-dependent rats.  Materials and Methods: Male Wistar rats were repeatedly administered with bi-daily doses of METH (2 mg/kg, subcutaneous) over a period of 14 days. Exercised ...

OBJECTIVE The root and stem barks of Eleutherococcus senticosus have been used to treat emotional and physical fatigue in China, Russia, Korea, and Japan. The effects of E. senticosus on recovery from physical fatigue and the expenditure of energy currently remain unclear. We herein examined the effects of E. senticosus extract on recovery from physical fatigue after the forced swimming test as...

Objective: Caryophyllus aromaticus mill L (Caryophyllus aromaticus) is a herbal spice plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of Caryophyllus aromaticus using forced swimming test (FST). Material and Methods: Three doses of ethanolic extract (50, 100 and 200 mg/kg) was i...

Icariin is recognized as the major bioactive component of Herba Epimedii. The aim of this study was to evaluate the anti-fatigue properties of icariin using a weight-loaded forced swimming test. The mice were randomly divided into four groups, a control group and three icariin treatment groups. The icariin treated groups received different doses of icariin per os (100, 200 and 400 mg/kg of body...