The him-8 gene is essential for proper meiotic segregation of the X chromosomes in C. elegans. Here we show that loss of him-8 function causes profound X chromosome-specific defects in homolog pairing and synapsis. him-8 encodes a C2H2 zinc-finger protein that is expressed during meiosis and concentrates at a site on the X chromosome known as the meiotic pairing center (PC). A role for HIM-8 in...

The intervening zone (IZ) is a pool of progenitor cells located at the midbrain-hindbrain boundary (MHB) and important for MHB maintenance, midbrain-hindbrain growth and the generation of midbrain-hindbrain neurons. Recently, we implicated the Hairy/E(spl) transcription factor Her5 in the formation of the medial (most basal) part of the IZ (MIZ) in zebrafish; the molecular bases for lateral IZ ...

Mutations in the him-5 gene in Caenorhabditis elegans strongly reduce the frequency of crossovers on the X chromosome, with lesser effects on the autosomes. him-5 mutants also show a change in crossover distribution on both the X and autosomes. These phenotypes are accompanied by a delayed entry into pachytene and premature desynapsis of the X chromosome. The nondisjunction, progression defects...

Grammatical Role Parallelism (Kamayama, 1986; Smyth, 1994) Reasoning/World Knowledge (Hobbs, 1979) a. George narrowly defeated John, and special interests promptly began lobbying him. [ him = George ] b. John was narrowly defeated by George, and special interests promptly began lobbying him. [ him = John ] c. George narrowly defeated John, and Mitt absolutely trounced him. [ him = John ] d. Geo...

I would like to make this personal request to viola teache;s: If you continue to teach a student beyond the beginning years, modify some of the things that you taught him initially. Explain to him why you taught him certain things at first and why you are now suggesting some refinements and exceptions: Tell him why you had to teach him that water seeks its own level, and show him why you now ha...

search for the cup of jamshid from me, years my heart made. and for what it possessed, from a stranger, entreaty made. a jewel that is beyond the shell of existence and of time, from those lost on the shore of the sea, search it made. last night, i took my difficulty to the pir of the magians. who, by strengthening of sight, the solving of sublety made. him, happy, laughing, wine-goblet in hand...

objective: fragile x syndrome is the second etiology for inherited mental retardation. it may concomitant with other psychiatric disorders. intellectual disability (id) is a state of functioning that typically begins in childhood and is characterized by limitations in intelligence and adaptive skills. we intend to introduce a male young patient with fragile x syndrome and obsessive-compulsive d...