Abstract A flexible problem-specific multiscale topology optimization is introduced to associate different areas of the design domain with diverse microstructures extracted from a dictionary optimized unit cells. The generation carried out by exploiting micro-SIMP AnisoTropic mesh adaptivitY (microSIMPATY) algorithm, which promotes free-form layouts. proposed methodology particularized in proof...

Diabetic foot ulcers occur in 1.9% of adults with diabetes annually [1], resulting in amputation in 15%– 20% of patients within 5 years [2]. Direct medical costs for diabetic ulcer care represent the majority of the estimated $4.6–$13.7 billion US annual expenditure for diabetic peripheral neuropathy [3]. Even modest improvements in the prevention and therapy of diabetic foot ulcers have the po...

One of the viral diseases affecting both domestic and wild animals in many countries around world is foot mouth disease (FMD). The livestock sector has been suffering significant financial losses for years as a result disease. present research work was focused on isolation, documentation serotyping Foot Mouth Disease (FMD) virus from different locations. Reverse Transcription Polymerase Chain R...

INTRODUCTION Walking barefoot is common in poorer developing countries which have large rural populations. Although high rates of foot injury could be expected among those who walk barefoot, walking barefoot as a risk factor for diabetic foot disease is rarely documented in the literature. METHODS Two preliminary clinical studies were undertaken to investigate whether there is a causal link b...