This paper proposed a new approach for integrated business-process-driven modeling and implementation for service-oriented enterprise applications. There are three phases in this approach: business environment modeling, business process modeling, and compiling. Business environment modeling employs a new modeling technique combining both the advantages of use case diagram and sequence diagram i...

In order to get a comprehensive repertoire of foldable domains within whole proteomes, including orphan domains, we developed a novel procedure, called SEG-HCA. From only the information of a single amino acid sequence, SEG-HCA automatically delineates segments possessing high densities in hydrophobic clusters, as defined by Hydrophobic Cluster Analysis (HCA). These hydrophobic clusters mainly ...

From Paper Craft to Protein Folding Guang Song Nan y M. Amato gsong s.tamu.edu amato s.tamu.edu Te hni al Report TR00-017 Department of Computer S ien e Texas A&M University July 21, 2000 Abstra t In this paper, we present a framework for studying folding problems from a motion planning perspe tive. The version of the motion planning problem we onsider is that of determining a sequen e of motio...

The number of protein structures is far less than the number of sequences. By imposing simple generic features of proteins (low energy and compaction) on all possible sequences we show that the structure space is sparse compared to the sequence space. Even though the sequence space grows exponentially with N (the number of amino acid residues) we conjecture that the number of low energy compact...

Lattice models, for their coarse-grained nature, are best suited for the study of the "designability problem," the phenomenon in which most of the about 16 000 proteins of known structure have their native conformations concentrated in a relatively small number of about 500 topological classes of conformations. Here it is shown that on a lattice the most highly designable simulated protein stru...