In this work, starch acetate and propanoate derivatives with moderate degree of substitution were synthesized and characterized for employment as matrix formers for sustained release from tablets. Matrix tablets were prepared from cospray-dried and simple physical mixtures of starch/starch derivatives and theophylline as a model drug. The release was rapid for matrix tablets prepared from simpl...

The present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (St-g-PMMA and Ast-g-PMMA) of starch and acetylated starch. Drug excipient compatibility was spectroscopically analyzed via FT-IR, which confirmed no interaction between drug and other excipients. Formulations were evaluated for physical characteristics like hardness,...

Sustained release tablets of Rosuvastatin were developed to prolong r e l e a s e o f time leading to an increase in drug bioavailability.Tablets are prepared by direct compression technique using polymers HPMC K15M,HPMC K50M and ethylcellulose.Tablets were evaluated for their physical characteristics viz.,hardness, thickness, friability and weight variation, drug content and floating propertie...

The aim of this study was to characterize the swelling and floating behaviors of gastroretentive drug delivery system (GRDDS) composed of hydroxyethyl cellulose (HEC) and sodium carboxymethyl cellulose (NaCMC) and to optimize HEC/NaCMC GRDDS to incorporate three model drugs with different solubilities (metformin, ciprofloxacin, and esomeprazole). Various ratios of NaCMC to HEC were formulated, ...

Zolmitriptan is the antimigraine agent widely used for treatment of migraine. It shows half-life 2.5 – 3 h which indicate frequent dosing to achieve proper pharmacological action drug. Gastro Retentive Drug Delivery System (GRDDS) a common approach decrease frequency and increase patient compliance, delivery drug through such an floating tablet formulation will meet requirement. This system sho...