Fisheries-induced evolution (FIE) has been reported for several intensively exploited fish stocks worldwide. Most studies focused on marine populations of high commercial interest , but FlE may also occur in intensively harvested fTesh water fish stocks. An example is the whitefish (Coregonus lavaretus) stock of Lake Constance. Previous evidence for FlE in this stock, tllrough tile analysis of ...

To evaluate the source location and clinical significance of rhythmic mid-temporal theta discharges (RMTD) by MEG in non-epileptic and epileptic patients, we conducted simultaneous MEG and EEG recordings with a whole-scalp 306-channel neuromagnetometer in three patients: one with right temporal lobe epilepsy (TLE), one with right frontal lobe epilepsy (FLE), and one with tension headache. We vi...

BACKGROUND Biomarker discovery research has yielded few biomarkers that validate for clinical use. A contributing factor may be poor study designs. METHODS The goal in discovery research is to identify a subset of potentially useful markers from a large set of candidates assayed on case and control samples. We recommend the PRoBE design for selecting samples. We propose sample size calculatio...

I am a second-year Epidemic Intelligence Service (EIS) officer assigned to the Centers for Disease Control and Prevention’s (CDC’s) National Environmental Public Health Tracking Program (Tracking Program). EIS offcers, commonly referred to as “disease detectives,” have opportunities to apply our skills to many public health activities beyond outbreak investigations and emergency response. One o...

PURPOSE Defining prognostic factors for neocortical epilepsy surgery is important for the identification of ideal candidates and for predicting the prognosis of individual patients. We use multivariate analysis to identify favorable prognostic factors for neocortical epilepsy surgery. METHODS One hundred ninety-three neocortical epilepsy patients, including 91 without focal lesions on MRI, we...

Catering Service of High-Speed Railway (CSHR) starts at suppliers, includes distribution centers and service stations in cities, and ends at cabinets in high-speed trains. In Distribution System Design (DSD) Problem for CSHR, it is critical to evaluate the alternatives of service stations, which is termed as Service Station Evaluation Problem in Catering Service of High-speed Railway (SSEP-CSHR...

A typical "cognitive profile" or defining behavioral syndrome for patients with frontal lobe epilepsy (FLE) has not been described. While there have been numerous reports of impaired "executive functions" in this population, the nature and severity of these deficits is highly variable, ranging from impaired attention to difficulty with the more complex behaviors involved in planning, selecting ...

PURPOSE To clarify the clinical usefulness of the dipole tracing method in evaluation of interictal EEG spikes in patients with partial epilepsy. METHODS Eight patients with partial epilepsy were studied. We compared the generator source of interictal spikes detected by the dipole tracing method with the results of magnetic resonance imaging (MRI), interictal/ictal measurement of cerebral blo...

A method for the first-order analysis of the point registration problem is presented and validated. The method is a unified approach to the problem that allows for inhomogeneous and anisotropic fiducial localization error (FLE) and arbitrary weighting in the registration algorithm. Cross-covariance matrices are derived both for target registration error (TRE) and for weighted fiducial registrat...