Lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes represent a group of rare genetic disorders of HDL metabolism that have been the subject of a large number of clinical, biochemical, and genetic studies. Of special interest are patients with LCAT-related disorders with severe HDL deficiency and the apparent absence of premature atherosclerosis. This finding is inconsistent with t...

BACKGROUND Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestingly it is also observed at low insulin states, such as prolonged fasting. Thus, we asked whether insulin is an independent modulator of hepatic lipid accumulation. METHODS/PRINCIPAL FINDINGS In mice we induced, hypo- and hyperinsulinemia associated FLD by diet induced obesity and str...

This research paper demonstrates authentic materials to enrich the student evaluation of teaching henceforward (SET) at Foreign Languages Department (FLD), namely; an electronic online questionnaire adopted from National Center for Academic Accreditation and Evaluation Taif University that was used as a  tool by students evaluate teachers' practices. It aimed mainly enhance sta...

Non-alcoholic fatty liver disease (NAFLD) and alcohol-related (ALD), both of them accounting for (FLD), are among the most common chronic diseases globally, contributing to substantial public health burden. Both NAFLD ALD share a similar picture clinical presentation yet may have differences in prognosis treatment, which renders early accurate diagnosis difficult but necessary. While is fastest...

Text processing methods like lexicon-based unsupervised approaches play important roles to quantify public opinions in the textual domain. While these have benefit directly generate sentiment scores from text data based on word-intensity scores, they perform poorly with shorter unstructured texts tweets. Besides, lexicon models often produce poor accuracy human annotated datasets. To overcome l...

The article argues that the EPP should be eliminated. It is shown that in a number of constructions the EPP does not hold at all. Where it does appear to hold, its effects follow from independent mechanisms of the grammar. EPP effects concerning the final landing site of A-movement follow from Case theory. Intermediate [Spec,IP]s are filled as a result of the requirement of successive cyclicity...

BACKGROUND Humans with familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) have extremely low or undetectable high-density lipoprotein cholesterol (HDL-C) levels and by early adulthood develop many manifestations of the disorder, including corneal opacities, anemia, and renal disease. OBJECTIVE To determine if infusions of recombinant human LCAT (rhLCAT) could reverse the an...

OBJECTIVE To compare the effectiveness of aspirin, warfarin, and ximelagatran as thromboprophylaxis in patients with non-valvular atrial fibrillation (NVAF). METHODS Systematic review of randomised controlled trials in patients with NVAF treated with adjusted-dose warfarin and aspirin, fixed low-dose (FLD) warfarin, ximelagatran or placebo. Outcome measures studied were ischaemic stroke, syst...