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AIMS Erythroblast transformation specific related gene (ERG), a proto-oncogene member of the erythroblast transformation specific transcription factor family, is a sensitive marker of endothelial differentiation and is expressed in vascular tumours, including angiosarcomas (AS). Immunohistochemistry is necessary for the diagnosis of AS in fine needle aspirates where low cellularity and lack of ...
Using a light-emitting diode (LED) built-in contact lens electrode, we studied the effect of age on short-wavelength sensitive cone electroretinograms (S-cone ERG) and long- and middle-wavelength sensitive cone ERGs (LM-cone ERG). We recorded ERGs in 31 pseudophakic subjects to avoid the effect of yellowing in the human crystalline lens. The intensities of our stimuli were on the asymptote of t...
Aims. We report on the discovery and properties of the fading afterglow and underlying host galaxy of GRB 071028B, thereby facilitating a detailed comparison between these two. Methods. Observations were performed with the Gamma-ray Burst Optical and Near-infrared Detector at the 2.2 m telescope on the La Silla Paranal Observatory in Chile. We conducted five observations from 1.9 d to 227.2 d a...
Accepted by The Astrophysical Journal Received ; accepted – 2 – ABSTRACT We present a high-energy study of the intriguing COS–B γ-ray field, 2CG 075+00, in order to search for possible counterparts. New EGRET data show that the COS–B emission probably corresponds to two localized γ-ray sources, 3EG J2016+3657 and 3EG J2021+3716. Spectral fits to these EGRET sources, assuming a power-law model, ...
BACKGROUND The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patie...
Genomic alterations involving translocations of the ETS-related gene ERG occur in approximately half of prostate cancer cases. These alterations result in aberrant, androgen-regulated production of ERG protein variants that directly contribute to disease development and progression. This study describes the discovery and characterization of a new class of small molecule ERG antagonists identifi...
To define genetic lesions driving leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming system using a hematopoietic-selective vav 1 oncogene (vav1) promoter. Leukemias of diverse lineages ensued, most commonly lymphoid leukemia and erythroleukemia. The inclusion of a transgenic allele of Janus kinase 2 (JAK2)V617F resulted in acceleration of trans...
PURPOSE Dark adaptation can induce a rapid functional shift in the retina, and after that, the retinal function is believed to remain stable during the continuous dark exposure. However, we found that electroretinograms (ERG) b-waves gradually shifted during 24 hours' dark exposure in rodents. Detailed experiments were designed to explore this non-classical dark adaptation. METHODS In vivo ER...
Sequential combination of cytogenetics and RNA-sequencing (RNA-Seq) has been shown to be an efficient approach to detect pathogenetically important fusion genes in neoplasms carrying only one or a few chromosomal rearrangements. We performed RNA-Seq on an acute myeloid leukemia in a 2-year-old girl with the karyotype 46,XX,add(1)(p36), der(2)t(2;3)(q21;q21),del(3)(q21),der(10)t(1;10)(q32;q24),d...
PURPOSE To assess differentially methylated "landscapes" according to prostate cancer Gleason score (GS) and ERG oncogene expression status, and to determine the extent of polycomb group (PcG) target gene involvement, we sought to assess the genome-wide DNA methylation profile of prostate cancer according to Gleason score and ERG expression. EXPERIMENTAL DESIGN Genomic DNA from 39 prostate ca...
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