There are a few reports in the literature implicating them causing fixed drug eruption, piperazine derivatives. In this case, although eszopiclone for insomnia medicinehas ring, no eruption appeared so far. Oxatomide and hydroxyzine not only shared ring but also two benzene rings via methine group (=CH–). It was suspected that structural became an antigenic determinant resulted cross-reactivity...

In March 2012, a Salvadoran-American boy aged 7 years living in Maryland developed three slightly painful, well-demarcated, flat, gray-brown patches on his torso. A dermatologist in Washington, DC, suspected a fixed drug eruption (an erythema multiforme-like adverse drug reaction that occurs in the same location each time the person uses a particular medication). The child had recently taken a ...