Evolutionary methods, such as genetic algorithms (GAs), provide powerful tools for optimization of the force field parameters, especially in the case of simultaneous fitting of the force field terms against extensive reference data. However, GA fitting of the nonbonded interaction parameters that includes point charges has not been explored in the literature, likely due to numerous difficulties...

Avian influenza viruses may be introduced into domestic poultry through migratory wild birds, particularly from Pakistan, which is situated across the migratory Indus flyway and holds more than 225 wetlands. To answer the question which areas should be given priority in surveillance and prevention with respect to notifiable avian influenza during the migratory season, a subset of Asian waterbir...

The systematics of indices of physico-chemical properties of codons and amino acids across the genetic code are examined. Using a simple numerical labelling scheme for nucleic acid bases, A=(-1,0), C=(0,-1), G=(0,1), U=(1,0), data can be fitted as low order polynomials of the six coordinates in the 64-dimensional codon weight space. The work confirms and extends the recent studies by Siemion et...

Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no structural information describing how the intersubu...

In this paper usefulness of time series based Auto Regressive (AR) modelling technique has been explored for identification of a person. For this purpose, time series is obtained from the contour coordinates of the ear. AR model is fitted to this time series. AR coefficients thus obtained serve as a feature vector. Recognition Rate (RR) has been found by a classifier that is based on Euclidian ...

The exponential fitting technique uses information on the expected behaviour of solution a differential problem to define accurate and efficient numerical methods. In particular, exponentially fitted methods are very effective when applied problems with oscillatory solutions. this cases, compared standard methods, they have proved be even using large integration steps. paper we consider Runge-K...

Mesh adaptation for immersed solid is one of the most challenging topics in computational mechanics. In this contribution, we propose a novel anisotropic adaptive body-fitted mesh method particular Computational Fluid Dynamics (CFD) where boundary layers and high gradient solution at fluid–solid interface play major role. It characterized by its simplicity to implement, generality tackle comple...