ARECENTLY published tabulation' of simple organic compounds reported to induce some weak fibrinolytic activity includes only compounds known to influence vasomotion (procaine, epinephrine, diethylaminoethanol). Studies in our laboratory concerning the influence of vasomotor drugs on the clotting mechanism have resulted in the observation that intravenously administered nicotinic acid induces ra...

The plasminogen/plasmin or fibrinolytic system with its physiological triggers, tissue-type plasminogen activator, and urokinase-type plasminogen activator has been presumed to participate in normal and pathological processes of the vessel wall such as blood clot dissolution (thrombolysis), hemostasis, aneurysm formation, neovascularization, restenosis, and atherosclerosis. The implied role of ...

Fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly influenced by clot structure, fibrinogen isoforms and polymorphisms, the rate of thrombin generation, the reactivity of thrombus-associated cells such as platelets, and the overall biochemical environment. Regulation ...

Thrombolytic therapy has become standard care in treating acute myocardial infarction. Fibrinolytic drugs such as streptokinase, APSAC and urokinase are non fibrin specific, and induce systemic activation of the fibrinolytic process, while t-PA and prourokinase are fibrin specific since they are able to activate mainly fibrin bound plasminogen. Both groups of thrombolytics exert different and o...

Successful treatment of traumatic hemothoraces is imperative to reduce morbidity and mortality among patients. Treatment modalities range from more conservative to invasive measures, including antibiotic therapy, thoracostomy tube placement, video-assisted thoracoscopic surgery, or thoracotomy. Various studies have documented success in using fibrinolytics such as tissue plasminogen activator (...

A non-invasive method has been developed for the study of tissue surface fibrinolytic activity during surgery in man. Surface exudate was collected using a filter-paper disc which was then applied directly to a fibrin plate or used to prepare a euglobulin fraction. The method detected the intraoperative increase in fibrinolytic activity. At 45 minutes from the start of surgery the increase in l...