Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with human acute myeloid leukemia (AML), but their role in oncogenesis is unclear. Here we demonstrate that the NUP98-HOXA9 fusion gene encodes two nuclear oncoproteins with either 19 or 37 NUP98 FG repeats fused to the DNA binding and PBX h...

Postweaning data on 643 rabbits from 122 litters representing four breed types, New Zealand White (NZW) and Californian (CAL) purebreds, CAL X NZW (CXN), and Flemish Giant (FG) crossbreds (the latter group was a collection of FG X CAL, FG X Champagne D'Argent [CHA], and 1/2 FG X 1/4 CAL X 1/4 CHA), were gathered over five seasons and compared for growth, feed efficiency, and survival-related pe...

• Let Ak denote the set of methods that observe a sequence of data pairs Y t = (F (θ, X ), F (τ , X )), 1 ≤ t ≤ k, and return an estimate θ̂(k) ∈ Θ. • Let FG denote the class of functions we want to optimize, where for each (F, P ) ∈ FG the subgradient g(θ;X) satisfies EP [‖g(θ;X)‖2∗] ≤ G. • For each A ∈ Ak and (F, P ) ∈ FG, consider the optimization gap: k(A, F, P,Θ) := f (θ̂(k))− inf θ∈Θ f (θ) ...

Let H be a separable Hilbert space, let G ⊂ H, and let A be an operator on H. Under appropriate conditions on A andG, it is known that the set of iterations FG(A) = {Ag | g ∈ G, 0 ≤ j ≤ L(g)} is a frame for H. We call FG(A) a dynamical frame for H, and explore further its properties; in particular, we show that the canonical dual frame of FG(A) also has an iterative set structure. We explore th...

The present study examined the fiber-type proportions of 22 muscles spanning the shoulder and/or elbow joints of three Macaca mulatta. Fibers were classified as one of three types: fast-glycolytic (FG), fast-oxidative-glycolytic (FOG), or slow-oxidative (SO). In most muscles, the FG fibers predominated, but proportions ranged from 25-67% in different muscles. SO fibers were less abundant except...

An evolutionary advantage of intrinsically disordered proteins (IDPs) is their ability to bind a variety of folded proteins-a paradigm that is central to the nucleocytoplasmic transport mechanism, in which nuclear transport receptors mediate the translocation of various cargo through the nuclear pore complex by binding disordered phenylalanine-glycine-rich nucleoporins (FG-Nups). FG-Nups are hi...

Cobalt-based superalloys are common materials for the manufacturing of various components used in aerospace applications. Conventional cobalt-based with a unimodal grain structure generally exhibit low strength and ductility at high temperatures. A bimodal superalloy, Co–20Cr–15W–10Ni (CCWN), was designed to achieve both The deformation behavior tensile properties CCWN alloy fine-grain (FG), co...

an experimental study was carried out on the wake of a cylinder on the back of which a plate is installed parallel to the fluid flow, with different terminal angles, where the reynolds number is 50000. at the end of the plate, blades with the height of 0.25 equal to the cylinder diameter and with 45, 90 and 135 degrees angle from the horizon, are installed where the cylinder diameter is equal t...

AIMS The aim of this study was to determine the specific spatiotemporal activation patterns of face perception in the fusiform gyrus (FG). The FG is a key area in the specialized brain system that makes possible the recognition of face with ease and speed in our daily life. Characterization of FG response provides a quantitative method for evaluating the fundamental functions that contribute to...

Fibrinogen (Fg) has been implicated in the pathogenesis of several fibrotic disorders by acting as a profibrotic ligand for a variety of cellular surface receptors and by modulating the provisional fibrin matrix formed after injury. We demonstrated increased renal Fg expression after unilateral ureteral obstruction and folic acid (FA) nephropathy in mice, respectively. Urinary Fg excretion was ...