background: given the paucity of data on possible testis changes in opioid dependents, we sought to compare the testis volumes between a group of opium dependents and a group of healthy controls. objective: comparison of testis volume between opium dependents and healthy controls. materials and methods: this case-control study recruited 100 men with opium dependency (cases) and 100 healthy men ...

the use of quantum dots (qdots) as bright and photostable probes for long-term fluorescence imaging is gaining more interest. thus far, (pre)clinical use of qdots remains limited, which is primarily caused by the potential toxicity of qdots. most qdots consist of cd2+ ions, which are known to cause high levels of toxicity. therefore, the cytotoxic effects of cdse quantum dots on embryonic devel...

AIM To create an information resource concerning multifactorial oncological diseases of the female reproductive system. MATERIALS AND METHODS A comprehensive search of the literature in the PubMed and Ukrainian scientific sources published from 1995 to 2014 and the results of researches performed in R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy...

Despite the arrival of newer imaging modalities, the increase of laparoscopic surgical techniques and the application of subservient reproductive techniques, hysterosalpingography remains one of the main radiological methods for the investigation of female infertility. The purpose of this article is to pictorially present the spectrum of pathological findings revealed with hysterosalpingography.

Telocytes (TCs) are a newly discovered type of cell with numerous functions. They have been found in a large variety of organs: heart (endo-, myo-, epi- and pericardium, myocardial sleeves, heart valves); digestive tract and annex glands (oesophagus, stomach, duodenum, jejunum, liver, gallbladder, salivary gland, exocrine pancreas); respiratory system (trachea and lungs); urinary system (kidney...

Phthalates are high-production-volume synthetic chemicals with ubiquitous human exposures because of their use in plastics and other common consumer products. Recent epidemiologic evidence suggests that women have a unique exposure profile to phthalates, which raises concern about the potential health hazards posed by such exposures. Research in our laboratory examines how phthalates interact w...

Apoptosis is a genetically programmed mechanism for a multicellular organism to remove cells that are unnecessary, or potentially harmful. The female reproductive system is characterised by a high rate of cellular proliferation. At the same time, apoptosis is also abundant during the normal physiological function of the ovary and endometrium. More than half of the 7 million oocytes that are pro...

Women have become increasingly physically active in recent decades. While exercise provides substantial health benefits, intensive exercise is also associated with a unique set of risks for the female athlete. Hypothalamic dysfunction associated with strenuous exercise, and the resulting disturbance of GnRH pulsatility, can result in delayed menarche and disruption of menstrual cyclicity. Speci...

There is now considerable epidemiological and experimental evidence indicating that early-life environmental conditions, including nutrition, affect subsequent development in later life. These conditions induce highly integrated responses in endocrine-related homeostasis, resulting in persistent changes in the developmental trajectory producing an altered adult phenotype. Early-life events trig...