Female Sprague-Dawley rats were exposed to a single, graded dose of either of two highly effective mammary chemical carcin ogens, 7,12-dimethylbenzanthracene (DMBA) or A/-methylnitrosourea, in order to determine the number of mammary cancers per rat induced by a range of carcinogenic doses. These data were then used to separately construct dose-response curves characteristic for DMBAand A/-meth...

In the urogenital system, simvastatin is associated with interstitial cystitis adverse effects, but exact mechanism not yet clearly defined. This study aims to determine effect of on eosinophilic inflammation bladder tissue in vivo. Laboratory experimental research design post-test only control group using 24 female Wistar rats aged 8-10 weeks were randomly divided into 50mg/kg BW (n=12) or pla...

Aim: Long term persistently high blood glucose levels result in various complications and conditions diabetic patients. One of them is gastrointestinal disorders the other increased risk infectious diseases like parasitosis. The aim study to demonstrate intestinal parasites with techniques patients confirm frequency parasites.Methods: A total 65 type 2 Diabetes Mellitus were included study. Lab...

Male urinary lipocalin family proteins, practically odorant-binding proteins but also could be pheromones by themselves, in rodents act as a shuttle for chemosignal communication and facilitate delivery of the signals for access to congeners. However, presence of this protein in urine of female rodents has not yet been reported. Therefore, the present investigation was carried out to find if li...

Many phase I and II enzymes are under hormonal regulation, resulting in sex-related expression patterns. This sex-related enzyme expression can result in differential metabolism of physiologically active endogenous substances, altered xenobiotic clearance, and differences in susceptibility to drug toxicities. Treatment of female Sprague-Dawley (SD) rats with 5 mg testosterone propionate/kg/day,...

OBJECTIVE To investigate the morphological changes in the peripheral motor system of the rat induced by exposure to lead. METHODS This study was conducted at the Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from January 2011 to January 2012. Female adult albino rats (n=10) were given lead acetate in their drinking water (500mg/L) for a pe...

objective: fetal development of the central nervous system is an important and sensitive stage which is affected by many external and internal stimuli. this study aimed to investigate effect of musical stimuli on fetal rat brain. materials and methods: in this experimental study, twelve female wistar rats were selected and evenly assigned to control and musical groups. the females were mated wi...

Pharmacological effects of camel urine (CU), its protein precipitate (PP), diluted urine (DU) and chloroformic extract (CE) were investigated. The PP inhibited the spontaneous movements of the isolated rat duodenum at a dose rate of 0.1ml/bath. Diluted female camel urine (0.4 ml/bath) or its protein precipitate (0.8 ml/bath) on rat fundus and rabbit jejunum revealed serotonin like effect which ...

Although gender and oestrogen treatment influence production of the vasorelaxant, NO, their influence on factors downstream in the NO signal-transduction pathway, specifically protein kinase G (PKG), remains unknown. We aimed to study the influence of sex hormones on PKG, along with the endothelial modulation of these effects, in rat thoracic aortic rings in two separate groups, control male an...