APGAR: Activity Pulse Grimace Appearance Respiration; PImax: Maximal Inspiratory Pressure; PEmax: Maximal Expiratory Pressure; DLCO: Diffusion Capacity; β-HCG: Bbeta Human Chorionic Gonadotropin; BMI: Body Mass Index; FVC: Forced Vital Capacity; FEV1: Forced Expiratory Flow at One Second; FEF25-75: Forced Expiratory Flow 25-75; RV: Residual Volume; TLC: Total Lung Capacity; DLCO/VA: Diffusion C...

S8 Figure 1. Ventilation images from (a) a healthy volunteer and (b-e) patients with mild CF. S9 SIFT-MS ANALYSIS AS A NON-INVASIVE DETERMINANT OF PSEUDOMONAS AERUGINOSA INFECTION IN PATIENTS WITH CYSTIC FIBROSIS R Pabary, S Kumar, J Huang, EWFW Alton, A Bush, GB Hanna, JC Davies; Royal Brompton and Harefield Hospital Foundation Trust, London, United Kingdom; Department of Cancer and Surgery, I...

BACKGROUND Understanding the environmental and genetic risk factors of accelerated lung function decline in the general population is a first step in a prevention strategy against the worldwide increasing respiratory pathology of chronic obstructive pulmonary disease (COPD). Deficiency in antioxidative and detoxifying Glutathione S-transferase (GST) gene has been associated with poorer lung fun...

Prospective study of 164 young men from the start of employment in grain elevators showed that of those seen at the initial evaluation of respiratory state only 30% were available for a complete four year follow up. The drop out of subjects could represent a health related selection leading to the underestimation of respiratory effects of exposure to grain dust as assessed in the survivor group...

BACKGROUND Lung function is altered by infection and rejection in patients who undergo heart-lung transplantation. The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. METHODS Thirty three patients who underwent heart-lung transplantation were followed for a mean period ...

OBJECTIVE To explore the relationship between prematurity, gender and chorioamnionitis as determinants of early life lung function in premature infants. METHODS Placenta and membranes were collected from preterm deliveries (<37 weeks gestational age) and evaluated for histological chorioamnionitis (HCA). Patients were followed and lung function was performed in the first year of life by Raise...

Background. Exposure to prenatal inflammation increases the risk for development of bronchopulmonary dysplasia. Aim. To evaluate the correlation between cord blood and gastric aspirate levels of interleukine-6 (IL-6) and interleukine-8 (IL-8) in preterm infants, and lung function at the age of 8 years. Methods. Between 2000-2002 we recruited 129 infants of gestational age < 30 wks. The concentr...

Background There is evidence that paternal and maternal lung function influence children’s pulmonary function. To date, the most widely used pulmonary function test (PFT) to assess airway responsiveness is the PC20 (concentration of methacholine required to decrease FEV1 by 20%). However, other measures of parental lung function may be better predictors of airway responsiveness or asthma develo...