We describe a newly recognized 40 kD FcR for IgG on human neutrophilic granulocytes. An mAb (IV3) developed against the IgG FcR of K562 cells, and specific as well for a 40 kD FcR on human monocytes and platelets, was found to purify by affinity adsorption a 40 kD protein from detergent lysates of surface-radioiodinated neutrophils. This protein, proteolytically degraded to 33 kD when purified ...

OBJECTIVE Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear. METHODS AND RESULTS We examined the effects of extended-release niacin (2 g/d) and extended-release niacin (2 g/d) plus lovastatin (40 mg/d), relative to placebo, on the kinetics of apolipoprote...

The effects of natural and recombinant human gamma-interferon (IFN-gamma) on mouse monoclonal antibody-dependent cellular cytotoxicity (ADCC) mediated by U937 human monocytic-like cells were examined. The efficiency of mouse monoclonal antibody of different isotypes in inducing ADCC was also compared. The number of receptors for the Fc portion of immunoglobulin G (IgG) (FcR) for mouse IgG2a and...

The safety and efficacy of ibrutinib, an oral inhibitor of Bruton tyrosine kinase, were evaluated with chemoimmunotherapy (CIT) in a multicenter phase 1b study. Patients with relapsed/refractory chronic lymphocytic leukemia received bendamustine and rituximab (BR) or fludarabine, cyclophosphamide, and rituximab (FCR) for up to 6 cycles with daily ibrutinib (420 mg) until progressive disease or ...

We have previously demonstrated that immunization with the inactivated Francisella tularensis, a Category A intracellular mucosal pathogen, combined with IgG2a anti-F. tularensis monoclonal antibody (Ab), enhances protection against subsequent F. tularensis challenge. To understand the mechanism(s) involved, we examined the binding, internalization, presentation, and in vivo trafficking of inac...

OBJECTIVES Residency training programs are required to assess and document residents' competency in communication. Multisource evaluations that include direct resident observations are preferred. Previous studies have often used methods of asking faculty members to evaluate residents on behaviors they did not witness. METHODS Twenty first year pediatric residents (interns) were evaluated prea...

-Edge detection has fundamental importance in image analysis. Classical edge detectors work only for specific image size and fail to operate on images with strong noise. Multiwavelets can achieve and maintain detail information of image well even in noisy environment. The steps involved in canny edge detector are performed in transformed domain (using DMWT) for synthetic image. Finally the perf...

Figure 1. External fixator. Figure 2. A Native uninjured wrist with the SLIL intact. B Injured wrist with SLIL dissociation. C Modified Brunelli tenodesis repair with the FCR graft looped over the dorsal radiotriquetral ligament and sutured onto itself. D Modified Brunelli tenodesis with interference screw fixation in the scaphoid and lunate with the FCR graft looped over The dorsal radiotrique...

A panel of 20 murine CD4+ clones was examined for the presence of surface membrane receptors for IgA, IgM, IgD, IgE, and IgG. High level expression of multiple Fc receptors (FcRs) was found on all Th2 clones. FcR expression was low or undetected on the Th1 clones. The preferential expression of FcR on activated Th2 cells suggests potential mechanisms for immunoregulatory interactions with B cells.

This paper discusses a class of Filtered Conjugate Residual Algorithms (FCR) as a way to compute the product of the exponential of a matrix by an arbitrary vector. These methods utilize implicitly expansions of the exponential function in a basis of orthogonal polynomials. FCR methods based on Laguerre, Hermite, and Chebyshev polynomials, are described and their performances are compared. The p...