Introduction: Metabolic syndrome (MetS) and impaired lung functions have been associated with an increased risk for coronary heart disease. The aim of this study was to investigate the pulmonary functions in patients with MetS. Methods: This cross-sectional study included 200 subjects with MetS in the study group and 100 subjects without MetS in the control group. Participants were examined...

OBJECTIVE Serum insulin levels are altered in insulin resistance and insulin deficiency, states that are associated with the development of type 2 diabetes. The goal of our study was to identify chromosomal regions that are likely to harbor genetic determinants of these traits. RESEARCH DESIGN AND METHODS We conducted a series of genetic analyses, including genome-wide and fine-mapping linkag...

Type 2 diabetes has been associated with high synthesis and low absorption of cholesterol independent of weight, indicating that insulin resistance may be a link between glucose and cholesterol metabolism. Therefore, we investigated the relationship of serum cholesterol precursors, reflecting cholesterol synthesis, and serum plant sterols and cholestanol, reflecting cholesterol absorption effic...

In this study, we examined the association between sugar-sweetened drink, diet soda, and fruit juice consumption and surrogate measures of insulin resistance. Sugar-sweetened drink, diet soda, and fruit juice consumption was estimated using a semiquantitative FFQ in 2500 subjects at the fifth examination (1991-1995) of the Framingham Offspring Study. Surrogate markers of insulin resistance meas...

Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder and one of the main reasons of infertility in women. PCOS causes many symptoms in women, one of the most important of them is ovulation failure. It affects the women at the age of fertility. Many factors are detected to exacerbate PCOS including insulin, anti-Mullerian hormone, obesity and androgen. The aim of this study was ...

The association of insulin resistance and body mass index (BMI) at age 13 years and change in insulin resistance and BMI from ages 13 to 19 years with systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19 years was studied in black and non-Hispanic white children. Insulin clamps were conducted at mean ages 13 (N=357), 15 (N=309), and 19 (N=224) years with in...

BACKGROUND Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity. METHODS Seventy-five subjects (2...