We report nine patients with muscle aching, cramps, stiffness, exercise intolerance, and peripheral nerve hyperexcitability. Neurologic examination showed calf fasciculations in seven, quadriceps myokymia in two, and deltoid myokymia in one patient. Two patients had mild increase in serum creatine kinase. Muscle biopsy showed either no abnormality (three patients) or mild neurogenic changes (fo...

The diagnosis of amyotrophic lateral sclerosis (ALS) is frequently challenging, and needle EMG plays a central role to assess lower motor neuron dysfunction. Ultrasonography can clearly visualize fasciculation, one of characteristic features of ALS, and could contribute to the diagnosis of ALS. Echogenicity might be useful to assess chronic denervated changes of muscles, although there are some...

In wild-type Drosophila embryos, five lateral chordotonal (lch) axons in each abdominal hemisegment originate from a midlaterally positioned cluster of neurons and grow, fasciculate, and orient ventrally as they connect with targets in the CNS. We have identified 22 recessive lethal mutations in 12 complementation groups, 8 of which are novel, that differentially affect lch axon growth, fascicu...

Hypoglossal nerve palsy is not common in literature, especially its physiotherapy assessment and management. We described a case of a 53 year old woman who presented clinically with right sided atrophy of the tongue, ipsilateral deviation and fasciculation, a speech defect, inability to swallow solids, and difficulty in swallowing fluid as a result of one year history of hypoglossal nerve palsy...

Motor neuron disease encompasses a group of progressive neurologic disorders that destroy cells responsible for the control of essential muscles. The disorders are characterized by progressive weakness, muscle atrophy and fasciculation, spasticity, dysarthria, dysphagia, and respiratory compromise. A 66-year-old male presented to the emergency department with progressive dyspnea and, ultimately...