Objectives The increase in paediatric patients suffering from chronic disease, often involves the transfer between different care sectors. The transition from the protected hospital environment to the patient’s home is often faced with difficulties and discomfort. Therefore it is essential to ensure proper management of the course of treatment and care of the child and his family, from admissio...

We examined a large consanguineous Druze family with McArdle disease for mutations in the glycogen myophosphorylase (PYGM) gene. All affected subjects were autozygous for a single G to A transition that abolishes the 5' consensus splice site in the first nucleotide of intron 14. The G to A transition is a rare mutation, with only one previous report in a single white subject heterozygous for th...

A method for family of G planar cubic Bézier spiral transition from straight line to circle is discussed in this paper. This method is then extended to a pair of spirals between two straight lines or two circles. We derive a family of cubic transition spiral curves joining them. Due to flexibility and wide range of shape control parameters, our method can be easily applied for practical applica...

Nanocomposite composed of organoclay(Cloisite 20A-C20A) and Poly lactic acid (PLA) was prepared by solvent casting method. Physical, mechanical, thermal, barrier and microstructure properties of the composite were studied. X-Ray diffraction (XRD) patterns and scannin...

The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100 proteins bind Zn2+, Cu2+, and/or Mn2+ as part of their biological functions; however, the evolutionary origins of binding remain obscure. One key question is whether divalent transition metal binding is ancestral, or instead arose independently on multiple lineages. To tackle th...

The conformational agenda harnessed by different glycosidases along the reaction pathway has been mapped by X-ray crystallography. The transition state(s) formed during the enzymic hydrolysis of glycosides features strong oxocarbenium-ion-like character involving delocalization across the C-1–O-5 bond. This demands planarity of C-5, O-5, C-1 and C-2 at or near the transition state. It is widely...

The declarative and relational aspects of Alloy make it a desirable language to use for high-level modeling of transition systems. However, currently, these models must be translated to another tool to carry out full temporal logic model checking. In this article, we show how a symbolic representation of the semantics of computational tree logic with fairness constraints (CTLFC) can be written ...

The relation between thermodynamic phase transitions in classical systems and topology changes in their configuration space is discussed for a one-dimensional, analytically tractable solid-on-solid model. The topology of a certain family of submanifolds of configuration space is investigated, corroborating the hypothesis that, in general, a change of the topology within this family is a necessa...

The relation between thermodynamic phase transitions in classical systems and topology changes in their configuration space is discussed for a one-dimensional, analytically tractable solid-on-solid model. The topology of a certain family of submanifolds of configuration space is investigated, corroborating the hypothesis that, in general, a change of the topology within this family is a necessa...