Colorectal cancers with widespread CpG island methylation display a number of distinct clinicopathological features, and it has been suggested that the condition has an inheritable genetic component. To address this possibility, histories of cancer were obtained from 562 individuals undergoing curative surgery for unselected colorectal cancer at one institution. Microsatellite status and methyl...

background: different viewpoints exist about lipid screening in all children or only in children with positive family history (fh)of premature cardiovascular diseases (cvds) or hypercholesterolemia. this systematic review and meta-analysis aim to assess the effectiveness of lipid screening in children and adolescents according to the existence of positive fh of cvd risk factors.materials and me...

The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased ...

OBJECTIVES This systematic review was undertaken to: (1) evaluate the accuracy of patient reporting of cancer family history, (2) identify and evaluate tools designed to capture cancer family history that are applicable to the primary care setting, and (3) identify and evaluate risk assessment tools (RATs) in promoting appropriate management of familial cancer risk in primary care settings. D...

BACKGROUND A family history, reflecting genetic susceptibility as well as shared environmental and behavioral factors, is an important risk factor for common chronic multifactorial diseases such as cardiovascular diseases, type 2 diabetes and many cancers. DISCUSSION The purpose of the present paper is to discuss the evidence for the use of family history as a tool for primary prevention of c...

Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. LTL was measured by PCR and compared across cases and controls as part of a study to examine the characteristics of paternal age related schizophrenia. The 53 schizophrenia cases had similar mean LTL as 20 controls, alth...

OBJECTIVES To investigate the characteristics and survival of lung cancer patients with additional malignant primary cancers. METHODS Records of lung cancer patients newly diagnosed in Shanghai Pulmonary Hospital between January 2000 and January 2010 were retrospectively reviewed. Patients with second primary lung cancer and those with lung cancer only were included for detailed analysis. R...

1: Department of Pediatrics, Bureau de l’Éthique Clinique, Université de Montréa; 2: Neonatology, Clinical Ethics Unit, Palliative Care Unit, Research Center, Unité de Recherche en éthique Clinique et partenariat famille, CHU Sainte-Justine, Montreal, Quebec, Canada. 3: Parent representative 4: Human Health Therapeutics, National Research Council, Montréal, Canada 5: UCL Elizabeth Garrett Ander...