Adenosine-5'-triphosphate (ATP) is consumed as a biological energy source by many intracellular reactions. Thus, the intracellular ATP supply is required to maintain cellular homeostasis. The dependence on the intracellular ATP supply is a critical factor in bioproduction by cell factories. Recent studies have shown that changing the ATP supply is critical for improving product yields. In this ...

While mapping total and poly-adenylated human transcriptomes has now become routine, characterizing nascent transcripts remains challenging, largely because nascent RNAs have such short half-lives. Here, we describe a simple, fast and cost-effective method to isolate RNA associated with transcription factories, the sites responsible for the majority of nuclear transcription. Following stimulati...

In today’s turbulent environment, companies are faced with two principal challenges. On the one hand, it is necessary to produce ever more cost-effectively to remain competitive. On the other hand, factories need to be transformable in order to manage unpredictable changes in the corporate environment. To deal with these different challenges, companies use the philosophy of lean production in t...

Nike and other brand companies have long been the target of widespread criticism for outsourcing their manufacturing production to contract factories with dismal working conditions. Despite the overwhelming amount of public interest, there exists no theory for studying this topic. The current paper fills this gap. In the model, the most productive firms in the North make high profits and outsou...

Cell factories are commonly microbial organisms utilized for bioconversion of renewable resources to bulk or high value chemicals. Introduction of novel production pathways in chassis strains is the core of the development of cell factories by synthetic biology. Synthetic biology aims to create novel biological functions and systems not found in nature by combining biology with engineering. The...

The paper discusses a proposal to use the Van Hengel Formula, or any similar formula, to establish basic standards for milling performance, boiling performance and undetermined losses: Relative efficiencies of the different factories> may then be readily comparetl by ranking their performances in each department against these standards. The method is illustrated by an analysis of the performanc...

Like many companies, Intel has evolved over the decades to provide competitive advantages through sophisticated automation—smart manufacturing—which has helped its factories increase product yields and quality, reduced costs, and improve safety. Intel’s smart factories are among those that now use edge computing and the Internet of Things (IoT) to enable automated control systems with real-time...

Production factories in which stable voltage is critical, e.g., electro-plating factory, require constantly stable voltage to minimize loss by adjusting incoming voltage in real time, even if low-quality electricity is supplied from outside. To solve such problem often being raised from the factories located in the area with unstable electricity supply, we designed N-M switching control system ...

This paper describes an approach to collaboratively improving processes in smart factories. It is based on the idea of a meta-process for continuous improvement that involves all stakeholders. The participation of human workers is seen as vital and is fostered using a set of technologies including wiki-based social software and the S-BPM approach to process management. The paper shows how these...

A near-infrared spectroscopy (NIRS) application was developed to discriminate Asiago d'Allevo cheese coming from different production chains (alpine farms, mountain and lowland factories). One hundred wheels were collected in different seasons from all productive sites of Asiago d'Allevo: 14 alpine farms and 8 mountain and 13 lowland factories. Samples were analyzed for chemical composition and...