Hemoglobins are ubiquitous in Eukarya and Bacteria but, until now, have not been found in Archaea. A phylogenetic analysis of the recently revealed microbial family of globin-coupled heme-based sensors suggests that these sensors descended from an ancient globin-only progenitor, or a protoglobin (Pgb). Here, we report the discovery and characterization of two Pgbs from the Archaea: ApPgb from t...

Bagnall and collegues1 report a technique to investigate an inversion that disrupts the factor VIII (F8) gene and that represents a frequent cause of severe hemophilia A. This large genomic rearrangement, identified for the first time by Brinke et al2 in 2 haemophilic monozygotic twins, affects intron 1 of the F8 gene. Bagnall et al1 demonstrated that this inversion of intron 1 derives from a h...

We study the origins of the inaccuracies of Schwinger’s nonet mass, and the Sakurai mass-mixing angle, formulae for the pseudoscalar meson nonet, and suggest new versions of them, modified by the inclusion of the pseudoscalar decay constants. We use these new formulae to determine the pseudoscalar decay constants and mixing angle. The results obtained, f8/fπ = 1.185±0.040, f9/fπ = 1.095 ± 0.020...

We exhibit seven linear codes exceeding the current best known minimum distance d for their dimension k and block length n. Each code is defined over F8, and their invariants [n, k, d] are given by [49, 13, 27], [49, 14, 26], [49, 16, 24], [49, 17, 23], [49, 19, 21], [49, 25, 16] and [49, 26, 15]. Our method includes an exhaustive search of all monomial evaluation codes generated by points in t...

in recent decades, most of researchers in pharmaceutical preparations have focused increasingly on new formulations that control the site and amount of drug delivery. mucoadhesive dosage forms are available for systemic or local treatment. the mucoadhesive dosage forms are introduced in various forms such as tablets, gels, ointments, patches and polymeric films. for buccal wound and injury the ...

Antigenic epitopes F8 (SIKEDVQF) and UB-33 (UreB fragment with residues 321-339: CHHLDKSIKEDVQFADSRI) in H. pylori urease that induces neutralizing antibody production were prepared on the cellulose plate from N- to C-terminus using CDMT as a coupling reagent. Reaction of both epitopes with sera of patients with medically confirmed atherosclerosis was studied. Strong, selective reactions of bot...

Previous studies have investigated the kinematics of racing wheelchair propulsion, but very few have focused on the kinematics of field events such as shot put, discus, and javelin . There are eight medical classes for wheelchair field athletes, F1-F8. However, there is no javelin competition for the F1 class. The growing popularity of these events have illuminated the need for kinematic analys...