Objective: The objective of this study was to find out the isotonicity chloramphenicol ophthalmic in situ gel and know irritating effect its eyes test animals, so it can be maximize absorption drug eye, minimize loss before corneal penetration safe used.
 Methods: This were started by making four aseptic formulations preparations with a comparison baseline concentrations different Poloxame...

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

269 INTRODUCTION Ophthalmomyiasis refers to infestation of the eye by dipterous fly larvae such as Chrysomyia bezziana. Chrysomyia bezziana is also known as old world screw worm; it is an obligatory parasite of the wound and found mostly in tropical and subtropical areas of the world. The sequelae of ophthalmomyiasis may range from minor irritation to blindness and even death. Treatment of opht...

A 10-year old boy accidently splashed acrylic adhesive in his left eye. I separated the eyelids by cutting adherent eyelashes with the use of a biomicroscope for magnification illumination. Tests with rabbits demonstrated that the solvent nitromethane dissolved the adhesions but diluted the glue and led to adhesions between the tarsal portion of the eyelid and the cornea. I used acrylic adhesio...

The side effects of topical dorzolamide hydrochloride, such as conjunctivitis, eyelid edema, and eye lid irritation, are well known. However, allergic contact dermatitis due to dorzolamide is rare, although the product has been commonly used worldwide in patients with glaucoma. To the best of our knowledge, this is the first report of allergic contact dermatitis caused by topical dorzolamide hy...

The non-cancer adverse health effects of formaldehyde are largely a manifestation of its ability to irritate mucous membranes. As a result of its solubility in water and high reactivity, formaldehyde is efficiently absorbed into the mucus layers protecting the eyes and respiratory tract where it rapidly reacts, leading primarily to localized irritation. Acute high exposure may lead to eye, nose...

1.1.1 Historical Background of In Vitro Ocular Irritation/Corrosion Test Methods and Rationale for Their Development The location of the eye and its anatomy predisposes it to exposure to a variety of environmental conditions (e.g., ozone, pollen) and substances on a daily basis. Injury from ocular exposure to a variety of chemical agents can lead to a range of adverse effects with the most extr...