Epithelial cell extrusion and subsequent apoptosis is a key mechanism to prevent the accumulation of excess cells. By contrast, when driven by oncogene expression, apical cell extrusion is followed by proliferation and represents an initial step of tumorigenesis. E-cadherin (E-cad), the main component of adherens junctions, has been shown to be essential for epithelial cell extrusion, but its m...

Streptococcus faecalis, like other bacteria, accumulates potassium ions and expels sodium ions. This paper is concerned with the pathway of sodium extrusion. Earlier studies (D.L. Heefner and F.M. Harold, Proc. Natl. Acad. Sci. USA 79:2798-2802, 1982) showed that sodium extrusion is effected by a primary, ATP-linked sodium pump. I report here that cells grown under conditions in which sodium AT...

The kinetic properties of cruciform extrusion in supercoiled DNA molecules fall into two main classes. C-type cruciforms extrude in the absence of added salt, at relatively low temperatures, with large activation energies, while S-type cruciforms exhibit no extrusion in the absence of salt, and maximal rates at 50 mM NaCl, with activation energies about one quarter those of the C-type. These di...

The objectives of this study were to determine the ileal and total tract digestibility of individual fatty acids, ether extract, energy, protein, and AA in a mix of flax and field pea (FP) and to determine whether extrusion improves the nutritive value of this mix. Five barrows (23-kg initial BW) fitted with a T-cannula at the distal ileum were fed 5 diets at 3 times the maintenance energy requ...

In this paper, an analytical method for noncircular shape extrusion is presented. Using this method, non-linear deformation field can be described with Hermit cubic spline which is prescribed by the boundary conditions of the die at its entryand exit. The upper bound method has been used to obtain optimum coefficient of the tangential boundary conditions. The results show that the optimum tange...

In this paper, an analytical method for noncircular shape extrusion is presented. Using this method, non-linear deformation field can be described with Hermit cubic spline which is prescribed by the boundary conditions of the die at its entryand exit. The upper bound method has been used to obtain optimum coefficient of the tangential boundary conditions. The results show that the optimum tange...

In this paper, a generalized expression for the flow field in axisymmetric extrusion process is suggested to be valid for any dies and the boundary shapes of the plastic deformation zone. The general power terms are derived and the extrusion force is calculated by applying upper bound technique for a streamlined die shape and exponential functions for shear boundaries. It is shown that assuming...

Vortex extrusion (VE) is a severe plastic deformation technique which is based on the synergies between high strain accumulation and high hydrostatic pressure. Such a high amount of pressure, places a mandate to seek the method for investigation of the load under processing conditions. For this, kinematically admissible velocity field and upper bound terms based on Bezier formulation are develo...

for many years, gutta-percha has been the root canal filling material of choice. chloroform is one of the most efficient solvents widely used for gutta-percha removal in retreatment cases, despite being toxic and carcinogenic. the present case report discusses a chloroform extrusion through an existing perforation to the surrounding periodontal ligament space and subsequent necrosis in supporti...

The main objective of this paper is to study the effect of extrusion parameters (extrusion stresses and temperature) and die geometry, i.e. extrusion radius, on the extruded aluminum quality using FEM Simulation Technique. For this purpose, the general FEA Software ABAQUS was used to set up the finite element model of the warm aluminum extrusion in two dimensions (2D). Aluminum alloy Al-2014 wa...