Primary mediastinal large B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) accounting for 2% to 4% of all non-Hodgkin lymphomas. We report a family of 3 siblings with PMBCL and their cousin with extranodal DLBCL. The histopathological characteristics of lymphomas of all 4 patients are similar, implying post-germinal center differentiation and growth deregulation by ...

Primary breast lymphomas (PBLs) represent less than 1% of all breast malignancies. Intravascular large B-cell lymphoma (ILBCL) is a rare, aggressive form of extranodal lymphoma. Breast involvement has only been described in the literature once previously. ILBCL is characterized by the proliferation of tumour cells within the lumen of small vessels of involved organs, resulting in their eventual...

primary hepatic lymphoma is a rare malignancy usually presenting with symptoms of fever, hepatomegaly, jaundice and weight loss. this picture mimics infectious and inflammatory disorders and thus delays the diagnosis. here, we present a 47-year old man with prolonged fever who underwent several investigations and, in the meantime, developed fulminant hepatic failure before the diagnosis could b...

Abstract Background Primary Breast Lymphoma is a rare manifestation of extranodal non-Hodgkin lymphoma and accounts for less than 1% all breast malignancies. It defined by localized involvement the mammary tissue lymphomatous infiltrate in absence prior extramammary concomitant widespread disease. Case presentation A 46-year-old melanodermic woman was referred to our hospital due an extensive u...

Clinical, histologic, cytogenetic, and molecular genetic data of 31 patients with extranodal, nodal, and splenic marginal zone B-cell lymphoma (MZBCL) are presented. Despite these variable clinical manifestations, a similar spectrum of morphologic features as well as distinctive immunophenotypic findings were noted. In all cases, a monotypic B-cell proliferation consistently negative for CD5, C...

Epstein-Barr virus (EBV) infection has been associated with a number of lymphoid malignancies, including endemic Burkitt’s lymphoma, some classical Hodgkin’s lymphoma, diffuse large B-cell lymphoma, extranodal NK/T cell lymphoma, and angioimmunoblastic T-cell lymphoma. A 59-year-old woman underwent an excisional biopsy for a left axillary mass under suspicion of malignant lymphoma. A preoperati...

Most non-Hodgkin’s lymphomas (NHL) in the head and neck region develop in the extranodal lymphatic system of the Waldeyer ring.1 Within the Waldeyer ring, the nasopharynx is the second most common site of disease after the tonsil. Primary nasopharyngeal lymphoma is much less common, occurring in only 8% of all NHL of the head and neck,2 and diffuse large B-cell lymphoma (DLBCL) is the most comm...

AIM To report the clinical and histological features and outcome of primary and secondary malignant lymphomas of the urinary bladder. METHODS Eleven cases of malignant lymphoma of the urinary bladder were obtained from the registry of cases at St Bartholomews and the Royal London Hospitals. The lymphomas were classified on the basis of their morphology and immunophenotype, and the clinical re...

CT findings were reviewed in 68 patients with untreated head and neck lymphoma. More than half of the patients with either Hodgkin's disease or non-Hodgkin's lymphoma were detected in the earlier stages (stage I or II). Four types of abnormalities were identified with CT: nodal involvement alone (type 1), extranodal involvement alone (type 2), a combination of extranodal and nodal disease (type...

Primary hepatic lymphoma represents <1% of extranodal lymphoma and predominantly seen in men older than 50 years of age. Exact etiology for these tumors is not certain yet, but presumed to be caused by certain viruses like Epstein-Barr virus and hepatitis C virus due to the frequent association of these viruses with disease. Most of these tumors are diffuse large B cell non-Hodgkin lymphoma. Di...