The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice ...

A 59-year-old builder presented to the accident and emergency department with a 4-week history of intermittent central chest pain. He was a lifelong non-smoker, had no asbestos or tuberculosis exposures, and had no cardiac risk factors. The patient’s pain settled with simple analgesia. Chest x ray showed a widening of the right paratracheal stripe consistent with right paratracheal lymphadenopa...

CONTEXT Antibiotics are the mainstay of treatment for bacterial infections in patients of all ages. Athletes who maximally train are at risk for illness and various infections. Routinely used antibiotics have been linked to tendon injuries, cardiac arrhythmias, diarrhea, photosensitivity, cartilage issues, and decreased performance. EVIDENCE ACQUISITION Relevant articles published from 1989 t...

Since the emergence of acquired immune deficiency syndrome (AIDS), tuberculosis and human immune defi­ ciency virus (HIV) infection have been intimately linked. Several studies have clearly shown that the incidence of active tuberculosis is increased in HIV infected patients (1). AIDS patients with tuberculosis have a higher inci­ dence of extra-pulmonary and pleural disease. The most common si...

Hepatitis C virus infection is an emerging disease and a public health problem in the world. There are accumulating data regarding extra hepatic manifestation of HCV, such as rheumatologic manifestations, endocrine, hematologic, dermatologic, renal, neurologic, and systemic manifestations. The therapy of them needs more attention to some exacerbations of extra hepatic manifestation and in some ...

a 64-year-old female with history of previous aortoiliac occlusion and aortoiliac bypass operation four months ago presented with dyspnea, ascites and leg edema. she has been suffering from bloody diarrhea since two weeks earlier. laboratory data showed important eosinophilia and stool examination was positive for strongyloides stercoralis. patient had clinical signs of heart failure. a cardiac...

Hepatitis E virus (HEV) infection can cause hepatic and extra-hepatic manifestations. Treatment of HEV infection has been thoroughly studied in solid-organ-transplant patients who have developed a chronic HEV infection. In this review, we report on our current knowledge regarding treatment of HEV infection.

Mycoplasma pneumoniae (Mp) is an important cause of pneumonia in paediatric age, but also other organs or systems can be affected even without pulmonary involvement. The purpose of this study is to stress the unusual clinical features of Mp infection in children. A review of children affected with Mp infection with peculiar pulmonary and/or extra-pulmonary forms is reported. Diagnosis of Mp inf...

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive M...

background and objectives:  helicobacter pylori cause a chronic gastric infection, and may cause extra gastrointestinal disease. the association between h. pylori infection and serum lipid profiles is still controversial. the aim of this study was to investigate any possible relationship between h. pylori infection and lipid levels. materials and methods: the subjects were 400 volunteer referr...