The cover shows the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE). PHF8 catalyzes hydroxylation of its H3 K9me2 substrate, EFE two competing reactions ethylene generation substrate l-Arg hydroxylation. Although both enzymes initially have an off-line 2-oxoglutarate (2OG) conformation, upon binding, forms in-line superoxo complex, whereas uses c...

INTRODUCTION Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare but severe congenital cardiac malformation. The prognosis mainly depends on the early and accurate diagnosis and treatment. However, without a typical and specific clinical manifestation in early stage, ALCAPA has a higher rate of false initial diagnosis. DIAGNOSTIC AND THERAPEUTIC PROCEDURE Three infants...

background     method.     results.     conclusion     edical education , e valuation , a ccreditation , s tandardization . regarding the importance of quality improvement in medical education, it is expected that even if this process would not lead to international accreditation acquisition, it will result in improvement and essential changes in basic medical education. keyword: m   having pri...

With the recent boom in impact evaluations around the world, policymakers in many sectors now have at their disposal an overwhelming amount of evidence about “what works” or at least what worked in a particular context. Yet as impact evaluations have multiplied, it has become apparent that “the same” policy can have very different effects in different populations (Vivalt 2016). Similarly, polic...

In this paper we address a fundamental problem of the standard one factor Gaussian Copula model. Within this standard framework a default event will have a large impact on the default probability of the survivors, through a shock in available information on the common factor. Moreover this effect is larger for defaults occurring instantaneously. In this paper it is shown that this problem is ca...