BACKGROUND Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targeting tumours with radiolabelled somatostatin analogues. This therapy induces abu...

INTRODUCTION Tumour and tumour-like lesions of the eyelids are more common in dogs than cats. In the feline, malignant tumours outnumber benign types, with eyelid neoplasms essentially arising from the haired skin. Based on 1 study, squamous cell carcinomas, fibrosarcomas and adenocarcinomas constitute 73.5 % of all feline eyelid tumours. Apocrine hidrocystomas in cats are rare, solitary and mo...

Malignant melanoma predominantly occurs in the skin and mucous membranes, thus, malignant melanoma of the breast is particularly rare. In the current study, a case of a 26-year-old female with a malignant melanoma of the breast is presented. On diagnosis of the patient, extensive metastasis had occurred. The patient refused any treatment and succumbed two months after the initial diagnosis. The...

Current treatment based algorithms for NSCLC are often derived from studies that were conducted prior to the extensive wealth of knowledge that was gained by subtyping lung cancer into distinct molecular entities. New studies are now helping to refine strategies for second-line approaches in EGFR-mutated, Alk-rearranged, as well as in EGFR/Alk-unmutated tumours. This review will focus on treatm...

An adult patient with the Proteus syndrome sustained a grade III splenic laceration after falling off a horse. Clinical features of this rare disorder include subcutaneous and visceral hamartomatous tumours. The patient also suffered from chronic intravascular coagulation associated with extensive haemangiomatosis (Kasabach-Merritt syndrome). Considering the visceral anomalies and abnormal coag...

Glial tumours associated with subarachnoid haemorrhage are very rare. A 64-year-old woman admitted with a history of 3 weeks seizures and a left sided hemiparesis and dysphasia. The magnetic resonance disclosed heterogeneously enhancing a right temporal mass. During surgery, suddenly an abrupt and extensive swelling had occurred both in tumour and the brain tissue. The surgery was completed wit...

The authors have reviewed 15 cases of orbital dermoids representing 6% of orbital tumours seen at the University of British Columbia Orbital Clinic. They tended to occur as either asymptomatic superficial lesions in children or as complicated deep lesions in adolescents and adults. The superficial lesions were as frequent medially as laterally and could be dealt with by a direct uncomplicated s...

of death from gynaecological cancer among women in Western countries. Epithelial ovarian cancer is responsible for 85-90% of all primary ovarian tumours. Because of the asymptomatic nature of the disease, ovarian cancer is usually not detected in the early stages and therefore many women present with advanced disease and systemic metastases. Approximately 70-80% of patients present with late st...

the presentation treatment and postoperative progress of two patients with pearly intraspinal eptdermcids is described. in one of the patients the tumour recurred after the first removal. necessitating a second operation. despite serious distur bances of gait both patients improved following surgery. the literature in respect of these tumours. is reviewed