ganoderma lucidum is one of the most well-known fungi, and has many applications in medicine. ganoderic acid is among the valuable secondary metabolites of ganoderma lucidum, and responsible for the inhibition of the tumor cell growth and cancer treatment. application of ganoderic acid has been limited because of low yields of its production from ganoderma lucidum. the present study aims to inv...

conclusions in this experimental study, for the first time in iran the expression and purification of this recombinant protein was done successfully. this recombinant protein could be used as a vaccine candidate and diagnostic purpose in subsequent investigations. results the highest expression of the cytochrome p450 cyp141 protein was obtained by the addition of 1 mm of isopropyl β-d-1-thiogal...

in this paper, we study the problem of minimizing the ratio of two quadratic functions subject to a quadratic constraint. first we introduce a parametric equivalent of the problem. then a bisection and a generalized newton-based method algorithms are presented to solve it. in order to solve the quadratically constrained quadratic minimization problem within both algorithms, a semidefinite optim...

conclusions this study indicated that the optimization of gene transfer increases the expression of igf-1. high concentrations of igf-1, in combination with cell therapy, have a significant effect on wound healing. results in vitro, the maximum expression of igf1 (96.95 pg/ml) in transfected fibroblast cells was 24 hours after gene transfer. in vivo, it was clear that igf-1 gene therapy caused ...