Introduction: The ginseng extract is an herb that has been used for many purposes such as analgesic effect. Dopamine D2 receptors are involved in the regulation of pain in humans. Therefore, the present investigation aims to study how pretreatment with aqueous-alcoholic extract of ginseng can affect dopamine D2 receptors’ pain sensitivity. Methods: We used 45 adult male rats weighing 250±20 fo...

AIMS The aim of the study was to explore the analgesic effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in acute experimental versus chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS-1) patients. METHODS Ten patients suffering from chronic CRPS-1 and with a Visual Analogue pain Score (VAS) of >5 were recruited. Seven intravenous 5-min low-dose S(+)...

OBJECTIVES This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain. DESIGN The study was designed as a randomized crossover trial, with each subject tested on 1 day. SETTING All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Intera...

Event-Related Potentials have been found to be related to subjective experience of experimental pain. But how are they related to the subjective experience of clinical pain? The current study investigated the predictive value of the pain ERP for the subjective experience of clinical pain. Event-Related Potentials in response to experimental pain were measured in 75 chronic low back pain suffere...

Introduction: People do health care not only to diagnose and relieve pain but also to reduce pain, anxiety, and loneliness in their daily lives. The present study aims to evaluate the effectiveness of Morita therapy among older women suffering from emotional distress and social isolation with chronic knee pain. Methods: The research method was pretest - posttest with a control group. The stati...