Intestinal mitochondria have a phospholipase D (PLD) activity which was stimulated by polyamines and monoamines resulting in the formation of phosphatidic acid (PA) from endogenous phospholipids. When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. S...

The levels of free, conjugated and bound polyamines (PA) were analyzed during the cell cycle of the synchronized unicellular green alga Scenedesmus obliquus. The polyamines putrescine (PUT) and spermidine (SPD) in their free and conjugated forms accumulated per cell to a maximum in the cell cycle at about the 16th hour after onset of illumination. The polyamines bound to macromolecules and memb...

Polyamines play a fundamental role in the functioning of all cells. Their regulatory plant development, their function under stress conditions, and metabolism have been well documented as regards both synthesis catabolism an increasing number species. However, majority these studies concentrate on levels most abundant polyamines, sometimes providing data enzyme activity or gene expression durin...

Ubiquitous in nature, polyamines are a group of aliphatic amines, cationic at neutral pH, that are essential for cell growth and viability. Because of their positive charge, polyamines are able to bind by electrostatic linkages to many cellular macromolecules, including DNA, RNA, and proteins (Kusano et al. 2008). Polyamines are involved in the regulation of a diverse range of vital cellular pr...

The purpose of this study was to examine the contribution of dietary polyamines toward preventing cardiovascular disease (CVD). Age-standardized mortality rates as well as other relevant information regarding individuals with CVD were gathered from the World Health Organization and the International Monetary Fund in 48 different European and other Western countries. Food supply data were collec...

The polyamines putrescine, spermidine and spermine are ubiquitously expressed cations that essential for normal cellular function. AMD1 is a key, rate limiting enzyme drives the conversion of putrescine to thus can change ratios three polyamines. polyamines, specifically spermine, show dramatic reduction in levels aged skin yet their role within not well understood. purpose this study was exami...

Red blood cell and plasma polyamines in umbilical and maternal blood at delivery were measured using high performance liquid chromatography. The concentration of each polyamine in red blood cells and plasma of umbilical blood was significantly higher than in maternal blood. Spermidine and spermine concentrations in fetal red blood cells decreased markedly with the progress of pregnancy. In addi...

During apoptosis, phosphatidylserine (PS) is moved from the plasma membrane inner leaflet to the outer leaflet where it triggers recognition and phagocytosis of the apoptotic cell. Although the mechanisms of PS appearance during apoptosis are not well understood, it is thought that declining activity of the aminophospholipid translocase and calcium-mediated, nonspecific flip-flop of phospholipi...