tuberculosis is an important opportunistic disease among hiv- infected persons worldwide; from march 1999 to feburery 2001 we had seventeen patients with hiv-infection and tuberculosis. here we are presenting the clinical manifestations, diagnosis, treatment and outcome of them. all of them were male, 11 patients had pulmonary and 5 patients had extrapulmonary (pleural effusion 1, hepatic granu...

Abstract Chronic lymphocytic leukemia (CLL) is the most common type of in adults and remains an incurable disease. Many patients with CLL are affected by non-malignant complications, including infectious diseases, as witnessed during past years, very high COVID-19 mortality rates. Accumulating data indicate that T cells might become exhausted CLL, which be a contributing factor to poor control ...

background: cd4+ and cd8+ t cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. the frequencies of t cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dln) can be considered as useful markers for evaluation of the immune system in cancers. methods: in this study,...

OBJECTIVES Counts of absolute CD4+ T lymphocytes (CD4+ T cells) are known to be highly variable in untreated HIV-infected individuals, but there are no data in virologically-suppressed individuals. We investigated CD4+ T cell variability in stable, virologically-suppressed, HIV-1 infected adults on combination antiretroviral therapy (cART). METHODS From a large hospital database we selected p...

UNLABELLED Most blinding ocular herpetic disease is due to reactivation of herpes simplex virus 1 (HSV-1) from latency rather than to primary acute infection. No herpes simplex vaccine is currently available for use in humans. In this study, we used the HLA-A*02:01 transgenic (HLA Tg) rabbit model of ocular herpes to assess the efficacy of a therapeutic vaccine based on HSV-1 gD epitopes that a...

Abstract Background and Aims Immune-senescence exhaustion have been described in hemodialysis (HD) patients, with changes lymphocyte phenotype possibly stimulated by the uremic environment, independent of age comorbid conditions. We evaluated potential association toxin accumulation count HD patients. Method In peripheral blood 54 patients (23 female, mean 51.3±16.91 years) 31 age-matched healt...

Abstract Background and Aims Hemodiafiltration (HDF) is characterized by enhanced clearance of middle molecular weight toxins therefore, it considered superior to hemodialysis (HD), especially in higher hemofiltration volumes. Although proinflammatory cytokines are lower HDF, its impact on immune phenotype has not been studied, so far. In this study we compared the lymphocytes’ senescent betwee...

The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection. Whereas the acute phase of the infection is dominated by virus-mediated depletion of memory CD4(+) T cells, chronic infection is often associated with a progressive decline of total CD4(+) T cells, including the naïve subset. The...

background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure c...