The ischemic process and reperfusion trigger different pathophysiological events, among them reduced adenosine triphosphate production, loss of ion pump homeostasis, increased intracellular calcium, formation of free radicals, inflammatory response, leukocyte activation, membrane depolarization with an excessive release of excitatory amino acids such as glutamate and dopamine, and induction of ...

BACKGROUND Alcohol withdrawal syndrome is a potentially life-threatening condition, which can occur when patients with alcohol use disorders undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and are known to play a key role in alcohol withdrawal syndrome. To understand this process better, we investigated the influence of isoflurane, sevoflurane, an...

This book represents the proceedings of a Satellite Symposium to the 30th Congress of the International Union of Physiological Sciences, held in Canada during July of 1986. It is the twenty-fourth volume of the neurology and neurobiology collection. The contents of the book are divided into seven sections, beginning with an overview of the field of excitatory amino acid transmission, and a disc...

the impact of pgf2? on total proteins, free amino acids and the amino transferases in the gonads of silkworm, bombyx mori l. were investigated in the present experiment. the effect of pgf2? resulted in increase in the total protein and free amino acid contents in the gonads of silkworm larvae indicating improved structural and dynamic levels of organization. the enhanced activity levels of amin...

Quorum sensing controls the luminescence of Vibrio fischeri through the transcriptional activator LuxR and the specific autoinducer signal produced by luxI. Amino acid sequences of these two genes were analyzed using bioinformatics tools. LuxI consists of 193 amino acids and appears to contain five α-helices and six ß-sheets when analyzed by SSpro8. LuxI belongs to the autoinducer synthetase fa...

We have recently reported that the cardiovascular responses to excitatory amino acids are augmented in the rostral ventrolateral medulla of spontaneously hypertensive rats (SHR). In the present study, we investigated whether the responsiveness to excitatory amino acids would be normalized by antihypertensive treatment. Thus we treated 4-week-old SHR and age-matched Wistar-Kyoto (WKY) rats with ...

BACKGROUND Nitric oxide has been implicated in the process of retinal ganglion cell death in glaucoma. OBJECTIVE To investigate the role of nitric oxide in mediating retinal ganglion cell death in a culture system that models glial-neuronal interactions at the level of the optic nerve head. METHODS Dissociated retinal ganglion cells from neonatal rats were plated on monolayers of astroglia ...

Denne afhandling er af Danmarks Farmaceutiske Højskole antaget til offentligt at forsvares for den farmaceutiske doktorgrad. For Anita, without whose support this would have been much harder. Preface i Preface No Man is an Island. This immortal phrase by John Donne also holds true when it comes to science. Thus the present thesis would not have been possible to write without the many fruitful c...