CONTEXT AND OBJECTIVE Nausea and vomiting are major inconveniences for patients undergoing chemotherapy. Despite standard preventive treatment, chemotherapy-induced nausea and vomiting (CINV) still occurs in approximately 50% of these patients. In an attempt to optimize this treatment, we evaluated the possible effects of carbamazepine for prevention of CINV. DESIGN AND LOCATION Prospective n...

Salicylate of soda omitted ; iron and arsenic given instead. llf/i January 1893.?He feels very drowsy. Heart's sounds irregular,?pulse rapid and weak. Temperature goes up every eveuing to 99?F. 13tli January 1893.? Yesterday he was made to fast, and then santonine given. He passed two round worms this morning. 22nd January 1893.?Disease changed to beriberi; drowsiness, swelling of the upper ext...

Midazolam hydrochloride and diazepam in emulsion were compared as i.v. sedatives for spinal anaesthesia. Mean doses of midazolam 12 mg and diazepam 27 mg were required to induce sleep and provide good or adequate sedation throughout surgery of approximately 1 h duration. Neither drug caused loss of the airway or significant cardiorespiratory changes. The frequency of drowsiness after operation ...

BACKGROUND There is little evidence that short-acting opioids as rescue medication for breakthrough pain is an optimal long-term treatment strategy in chronic non-malignant pain. We compared clinical studies of long-acting opioids that allowed short-acting opioid rescue medication with those that did not, to determine the impact of opioid rescue medication use on the analgesic efficacy and tole...

Disturbances of the circadian timing system following daylight saving time (DST) may influence the symptoms of Parkinson's disease (PD). To address this question, we compared the severity of motor fluctuations and non-motor symptoms both before and after the time change. Total daily "off-time" based on diaries, excessive daytime sleepiness (Epworth Sleepiness Scale), depressive symptoms (Beck D...

The literature on the effects of various levels of nitrous oxide is reviewed. The rapid uptake and excretion of the gas facilitates the recognition of four levels or zones depending upon the concentration used. In the lightest level of nitrous oxide, Zone 1, moderate analgesia is present with few side effects. In Zone 2 psychological side effects of dissociation are present in addition to more ...

Within most baseball fields there is a non-turfed basepath surface in addition to a turfed playing surface that can be either natural or synthetic. Two important properties of any playing surface are its ability to absorb the energy generated upon impact (surface hardness) and the level of traction it provides to the athlete during play. Studies were conducted to determine the effects of varyin...

Delirium is the abrupt onset of fluctuating confusion, inattention, and reduced awareness of the environment. Symptoms can affect different areas of cognition (memory, orientation, language, visuospatial ability, or perception) and may include hallucinations and disturbances in the sleep-wake cycle (box 1). Delirium can therefore be distressing to people who experience it and those around them....

Controversy regarding the optimal design for neonatal intensive care has existed for more than 20 years. Recent evidence confirms that in comparison with the traditional open-bay design, the single-room facility provides for improved control of excessive noise and light, improved staff and parental satisfaction with care and equal, or possibly reduced, cost of care. Single-room care was not ass...

CAN J ANESTH 54: 1 www.cja-jca.org January, 2007 by some authors that the tip of the cannula should be withdrawn outside the lumen of the vein and sited subcutaneously to avoid the rare complication of air embolism.4 It has also been suggested that this method will protect the catheter from kinking. The circumstances of this case challenge that assumption, and suggest that it may be preferable ...