This method is based on the intravenous injection of Evans Blue in mice as the test animal model. Evans blue is a dye that binds albumin. Under physiologic conditions the endothelium is impermeable to albumin, so Evans blue bound albumin remains restricted within blood vessels. In pathologic conditions that promote increased vascular permeability endothelial cells partially lose their close con...

The Morris water maze task was originally designed to assess the rat's ability to learn to navigate to a specific location in a relatively large spatial environment. This article describes new measures that provide information about the spatial distribution of the rat's search during both training and probe trial performance. The basic new measure optimizes the use of computer tracking to ident...

We develop a general instability index theory for an eigenvalue problem of the type Lu = λu′, for a class of self-adjoint operators L on the line R. More precisely, we construct an Evans-like function to show (a real eigenvalue) instability in terms of a Vakhitov-Kolokolov type condition on the wave. If this condition fails, we show by means of Lyapunov-Schmidt reduction arguments and the Kapit...

PURPOSE This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown. METHODS Blood-retinal barrier breakdown was induced in rats with vascular endothelial growth factor (VEGF) or through the induction of diabetes. After allowing Evans blue to circulate in the vasculature,...

This paper consists of two parts. In section I, I explore Christopher Hookway’s proposal (1988) to elude a counter-example which Gareth Evans [Evans (1975)] offers against Quine’s Thesis of the Inscrutability of Reference. Evans produced a line of argument which suggests that one of Quine’s semantically perverse translation manuals is behaviourally incorrect. Hookway modifies the perverse manua...

Potential predictors of systolic and diastolic blood pressure change between 1960 and 1967 in the biracial population of Evans County, Georgia, were investigated. An all possible regressions multiple linear regression analysis was used. For systolic blood pressure change, the level of systolic blood pressure, age, and change in Quetelet index were significant (p less than 0.05) correlates in wh...

Traditionally, biomedical research has been carried out mainly within departmental boundaries. However, successful biomedical research increasingly relies on development of methods and concepts crossing these boundaries, requiring expertise in different disciplines. Recently, major research institutes have begun experimenting with ways to foster an interdisciplinary ethos. The Evans Center for ...

In the present study, the effect of Datura steramonium (DS) seed extract on acute inflammation induced by formalin injection was investigated. For this purpose, two control and treatment groups were selected and in order to induce pain, formalin (50 µl, 2.5%) was applied to the plantar surface of hind paws. In treatment group, 20-30 min before formalin injection, the DS seed extract was used i....

The results of calculations of gas emission spectra with both central and extended sources of ion-ization have been compared to the ratio of line intensities observed in the extended narrow line region of NGC1068. The origin of an extended structure of anomalous strength in the OIII]5007 and NeV ]3425 lines found by Evans & Dopita (1986) and Bergeron et al.(1989) could be due to an additional s...

We describe an accelerated density functional theory (DFT)-based computational strategy to determine trends in the decomposition of glycerol via elementary dehydrogenation, C-C, and C-O bond scission reactions on close-packed transition metal surfaces. Beginning with periodic DFT calculations on Pt(111), the thermochemistry of glycerol dehydrogenation on Pd(111), Rh(111), Cu(111) and Ni(111) is...