The monolithic matrix type transdermal drug delivery system of metoprolol tartrate were prepared by the film casting on a mercury substrate and characterised in vitro by drug release studies, skin permeation studies and drug-excipients interaction analysis. Four formulations were developed, which differed in the ratio of matrix-forming polymers. Formulations MT-1, MT-2, MT-3 and MT-4 were compo...

BACKGROUND AND THE PURPOSE OF THE STUDY Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its selectivity and specificity on the smooth vascular cells. The pharmacokinetic parameters make LRDP a suitable candidate for transdermal delivery. The purpose of the study was to select a suitable formulation for the development of transdermal drug-delivery system (T...

in recent years, researches on reinforcement learning (rl) have focused on bridging the gap between adaptive optimal control and bio-inspired learning techniques. neural network reinforcement learning (nnrl) is among the most popular algorithms in the rl framework. the advantage of using neural networks enables the rl to search for optimal policies more efficiently in several real-life applicat...

Objective: Azelnidipine, a long-acting dihydropyridine based calcium channel blocker, on oral administration, the drug undergoes extensive first pass metabolism. Delivery of azelnidipine (AZP) via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, is to investigate the development and ev...

Abstract: Background: The objective of this current study was to fabricate and characterize the sustained release double layered transdermal patches Diclofenac Diethylamine using hydrophobic acrylic polymer Eudragit RL 100 hydrophilic Polyvinyl pyrrolidone K-30 in combination as first layer matrix type patch pressure sensitive adhesive Duro Tak 387- 2510 second drug-in-adhesive provide anti-inf...

Supporting for updating XML documents has recently attracted interest. This paper presents a novel declarative XML update language, which is an extension of the XML-RL query language. We define XML-RL update syntax and a set of primitive update operations to fully evolve XML into universal data representation and sharing format.