Icosapent ethyl is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester approved at a dose of 4g/day as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500mg/dL) hypertriglyceridemia. This post-hoc exploratory analysis examined the relationship of icosapent ethyl dose with EPA concentrations in plasma and red blood cells (RBCs) across ...

The aim of the study was to determine whether fatty acid ethyl esters, nonoxidative products of ethanol metabolism selectively present in organs damaged by ethanol abuse, are detectable in the serum after ethanol ingestion. Serum samples of hospital emergency room patients with positive (n = 32) and negative (n = 5) blood ethanol levels were assayed for fatty acid ethyl esters. In a separate st...

A commercial nonylphenol (NP) reagent was separated into 14 fractions, NP1 to NP14 using a gas chromatograph equipped with a preparative fraction collector (GC-PFC). The identifi cation of the major components of 14 fractions was attempted by analysis of their nuclear magnetic resonance (NMR) spectra, and the estrogenicity of the isomers was tested in a recombinant yeast screen system. Eleven s...

INTRODUCTION Patients receiving statin therapy for dyslipidaemia often require treatment with an additional agent to control triglyceride levels. Options for add-on therapy include fibrates and omega-3 fatty acids. This case series describes the effects of switching add-on therapy from fenofibrate to icosapent ethyl (the ethyl ester of the omega-3 fatty acid, eicosapentaenoic acid) on patient l...

AIMS This study examined the possibility of using hair samples other than scalp hair for analysis of fatty acid ethyl esters (FAEE) as markers for alcohol misuse. METHODS Samples of scalp and pubic hair and, if available, axillary, beard and body hair of one teetotaller, five moderate social drinkers and 22 fatalities were analysed for FAEE by head-space solid-phase microextraction and gas ch...

Methanolic extracts of rice hulls with or without far infrared (FIR) irradiation were sequentially fractionated with solvents (hexane, chloroform, ethyl acetate, butanol, and water), and antioxidant activities of the fractions were analyzed for total phenol contents (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging capability, reducing power, and antioxidant potency. Yield of chlor...

synthesis of 4-(n,n- dimethylamino)-3-aryl-3-butene-2-one, ethyl-5-aryl-4-oxo-4h-pyran-2-carboxylate, ethyl-5-aryl-4-pyridones-2-carboxylate and 5-aryl-3-cyano-5-methyl-2-pyridones (aryl=3-thienyl, 2-furyl) are described.

BACKGROUND Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and simple lipophilic ester, has been shown to have anti-inflammatory properties. ...

Ethyl methanesulfonate is a synthetic compound widely used as a mutagen, teratogen and brain carcinogen and as a research chemical. While, the toxicity and carcinogenicity of ethyl methanesulfonate on humans and animals have been studied, less is known about its genotoxicity to plants. In this study, the genotoxic effects of ethyl methanesulfonate were investigated with growing chilli seedlings...

Static headspace gas chromatographic (SHS-GC) analysis was performed to determine the release of 13 odorants in hydrocolloid model systems containing original or regio-selectively carboxylated cellulose at different pH values. The release of most odor compounds was decreased in the hydrocolloid solutions compared to control, with the amounts of 2-propanol, 3-methyl-1-butanol, and 2,3-butanedion...