A green chemistry-based highly regioselective synthesis of ethyl (9-anthryl)glyoxylate was achieved by solvent-free Friedel-Crafts reaction at r. t. Several derivatives of ethyl (9-anthryl)glyoxylate were also synthesized. Ethyl (9-anthryl)hydroxyacetate was obtained almost quantitatively by reduction of ethyl (9-anthryl)glyoxylate with NaBH4, and (9-anthryl)methoxyacetic acid was prepared by m...

Acetaminophen, a common analgesic/antipyretic, is a frequent cause of acute liver failure in Western countries. The development of an effective cure against acetaminophen hepatotoxicity is crucial. Ethyl pyruvate, an ethyl ester derivative of pyruvic acid, has been identified as a possible candidate against acetaminophen hepatotoxicity in animal experiments. However, the mode of the hepatoprote...

Preservation using combinations of antibacterial molecules has several advantages, such as reducing the level usage and broadening their antimicrobial spectrum. More specifically, use quaternary ammonium surfactants (QAS)—which are profusely used in hair care products some known efficient agents—is limited due to potential cytotoxicity concerns. This study shows that concentration widely cosmet...

background : vitiligo is an acquired disease of skin that presents with depigmented patches due to lack of melanocytes in the epidermis. accumulation of toxic free radicals like hydrogen peroxide in the epidermis may be responsible for melanocytes death. since ethyl vanillate (vanillic acid ethyl ester) is a strong hydrogen peroxide scavenger, it may be effective against vitiligo. this study wa...