The ability of organ cultures of normal human and rat bladder to metabolize the polycyclic hydrocarbon, benzo(a)pyrene (BP), and the arylamine, 2-acetylaminofluorene, has been studied. Cultures were maintained for 0 to 6 days in a chemically defined medium before incubation with [3H]BP (0.3 to 0.5 microM) or 2-[14C]acetylaminofluorene (18 to 25 microM) for 24 hr. Ethyl acetate-soluble and water...

Context. We have performed a spectral line survey called EMoCA toward Sagittarius B2(N) between 84.0 and 114.4 GHz with the Atacama Large Millimeter/submillimeter Array (ALMA) in its Cycles 0 and 1. Line intensities of the main isotopic species of ethyl cyanide and its singly 13C-substituted isotopomers observed toward the hot molecular core Sagittarius B2(N2) suggest that the doubly 13C-substi...

De-esterification is an initial step in the metabolism of certain herbicides, for example, fenoxaprop-ethyl [(+/-)-ethyl 2-[4-[(6-chloro-2-benzoxaolyl)oxy]phenoxy]propanoate] (FE). The ethyl-ester bond cleavage of FE to fenoxaprop acid (FA) by purified enzymes, crude bacterial enzyme preparations, and soils was investigated. In similar experiments fluorescein diacetate (FDA) was used as an alte...

The ability of organ cultures of normal human and rat bladder to metabolize the polycyclic hydrocarbon, benzo(a)pyrene (BP), and the arylamine, 2-acetylaminofluorene, has been stud ied. Cultures were maintained for 0 to 6 days in a chemically defined medium before incubation with [3H]BP (0.3 to 0.5 ¿IM) or 2-pC]acetylaminofluorene (18 to 25 ¡ÕM) for 24 hr. Ethyl acetate-soluble and water-sol...

Abstract Internally plasticized PVC copolymers were prepared by grafting with butyl acrylate and 2-(2-ethoxyethoxy)ethyl atom-transfer radical polymerization, resulting in well-behaved polymers a wide range of glass transition temperatures (–54 °C to 54 °C). When the grafted side chains made up more than 50% polymer weight, below 0 °C. The covalent attachment plasticizing grafts requires one si...

AIMS Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are conjugated ethanol metabolites formed in low amounts after alcohol consumption. Compared with ethanol, EtG and EtS are excreted in urine for a prolonged time, making them useful as sensitive alcohol biomarkers. This study determined the detection times for EtG and EtS in alcoholic patients undergoing alcohol detoxification. METHODS Alco...

The hematological effects of three sugar derivatives of nitrosoureas, Chlorozotocin (2-[(chloro-2-ethyl)-3-nitrosoureido]-Dglucopyranose), (chloro-2-ethyl)-1-(ribopyranosyl triacetate2',3',4')-3-nitrosourea, and (chloro-2-ethyl)-1-ribofuranosylisopropylidene-2',3'-p-nitrobenzoate-5')-3-nitrosourea, were studied in the bone marrow, spleen, and peripheral blood of mice. The three compounds were i...