Proses induk lele (Clarias gariepinus Burchell) betina menjadi matang gonad secara alami memakan waktu hingga 2-3 bulan, dengan tingginya permintaan benih diperlukan percepatan proses pematangan agar dapat terpenuhi, salah satunya melalui pemberian hormon ethinylestradiol. Kandungan optimum ethinylestradiol pada tubuh akan mempercepat vitellogenesis sehingga memacu pertumbuhan oosit dan kematan...

BACKGROUND Ethinylestradiol was used as palliative treatment for patients with advanced prostate cancer (PCa). However, its use has declined after the development of combined androgen blockade. In the present study, we analyzed the effects of ethinylestradiol on pretreated castration-resistant PCa patients. PATIENTS AND METHODS Twenty-four Japanese patients were orally administered ethinylest...

background: hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of tnfα which in turn induces more lipogenesis.omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. objectives: in this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. methods:2 mg/kg. bw/s...

OBJECTIVE To investigate if continuation rates in first-time users of oral hormonal contraceptives differed between different formulations and to measure if the rates were related to the prescribing categories, that is, physicians and midwives. DESIGN A longitudinal national population-based registry study. SETTING The Swedish prescribed drug register. PARTICIPANTS All women born between ...

Estrogen-induced cholestasis is characterized by impaired hepatic uptake and biliary bile acids secretion because of changes in hepatocyte transporter expression. The induction of heme oxygenase-1 (HMOX1), the inducible isozyme in heme catabolism, is mediated via the Bach1/Nrf2 pathway, and protects livers from toxic, oxidative and inflammatory insults. However, its role in cholestasis remains ...

Recently, YY super-male yellow catfish had been created by hormonal-induced sex reversal and sex-linked markers, which provides a promising research model for fish sex differentiation and gonad development, especially for testis development. MicroRNAs (miRNAs) have been revealed to play crucial roles in the gene regulation and gonad development in vertebrates. In this study, three small RNA lib...

Parental full life-cycle exposure to ethinylestradiol (EE₂) significantly affects embryo development and survival. One of the possible mechanisms of action of EE₂ may involve the impairment of an organism's ability to repair DNA damage. DNA repair mechanisms have sophistically evolved to overcome DNA damaging hazards that threaten the integrity of the genome. In the present study, changes in th...

Each active light yellow tablet contains: Ethinylestradiol 30 micrograms Drospirenone 3 mg For full list of excipients, see section 6.1 List of excipients. 3. PHARMACEUTICAL FORM YASMIN active tablet Light yellow round film-coated tablets marked on one side with the letters “DO” in a regular hexagon, each containing drospirenone 3 mg and ethinylestradiol 30 μg. YASMIN placebo tablet White, roun...

Environmental Protection includes programs that are aimed to reducing risks the environment from hazardous materials and chemical wastes. Nowadays, 17α-ethinylestradiol, a synthetic estrogen, has become one of most commonly used active ingredients for oral contraception, interfere with normal functioning endocrine systems, thus affecting reproduction development in wildlife. The fresh water foo...

Several environmental xenobiotics have been found to affect the metamorphosis of amphibians. In this study we exposed tadpoles of the Common frog Rana temporaria from hatching to metamorphosis to two known endocrine disruptors, the estrogenic pharmaceutical 17 -ethinylestradiol and the antiandrogenic/antiestrogenic fungicide prochloraz to determine their effect on 1) days to metamorphosis and s...