The previous observation (BABIOR, B. M., J. Biol. Chem., 244, 449 (1969)) that the tritium isotope effect for the coenzyme B,,-dependent deamination of ethanolamine was smaller than the deuterium isotope effect prompted a reexamination of the various isotope effects observed in this reaction. Measurements of the rates of deamination of [l-D]and [l,l-Dn]ethanolamine showed that no secondary isot...

Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol. Ethanolaminephosphotransferase catalyses an analogous reaction with CDP-ethanolamine as the phosphobase donor for the synthesis of phosphatidylethanolamine (PtdEtn). Together these two enzyme activities ...

Ethanolamine ammonia-lyase catalyzes the adenosylcobalamin (AdoCbl)-dependent conversion of ethanolamine to acetaldehyde and ammonia. It has been proposed that the mechanism of this and other AdoCbl-dependent rearrangements involves the formation and rearrangement of an organocobalamin in which a substrate fragment is coordinated to the corrin metal by a carbon-cobalt bond. In the case of ethan...

It will be noted from the large standard deviations of the top half of Table 1 that the material proved rather variable. There are some indications that 3,3-tetramethyleneglutarate has a greater effect on fructose pool size in dystrophic muscle, but this cannot be proved statistically on this sample. The lower half of Table 1 shows an effect of 3,3tetramethyleneglutarate on fructose labelling, ...

The bis-retinoid pigments that accumulate in retinal pigment epithelial cells as lipofuscin are associated with inherited and age-related retinal disease. In addition to A2E and related cis isomers, we previously showed that condensation of two molecules of all-trans-retinal leads to the formation of a protonated Schiff base conjugate, all-trans-retinal dimer-phosphatidylethanolamine. Here we r...