Both myocardial and plasma endothelin-1 (ET-1) are elevated in congestive heart failure (CHF). However, the role played by endogenous ET-1 in the progression of CHF remains unknown. The aim of the present study was to investigate and correlate myocardial gene expression programs and left ventricular (LV) remodeling during chronic ET-receptor antagonism in CHF rats. After ligation of the left co...

in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: An observational study. Lancet 2003;361:1077–1083. 4. von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: Facts and numbers. J Cachexia Sarcopenia Muscle 2010;1:1–5. 5. von Haehling S, Lainscak M, Springer J et al. Cardiac cachexia: A systematic overview. Pharmaco...

The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving acceptance as complimentary therapy in addition to routi...

OBJECTIVES We investigated the effects of long-term endothelin A (ET(A)) receptor blockade and ACE inhibition, either alone or in combination, on the hemodynamics, neurohormonal activation and cardiac remodeling in rats with congestive heart failure (CHF) after extensive myocardial infarction (MI). METHODS Rats were treated with placebo, the ET(A) antagonist LU135252 (30 mg/kg/d), the ACE inh...

Aortic aneurysm (AA) is a life threatening condition. Large AA carries a substantial risk of rupture. Observational studies have reported a 14.1% annual incidence rate of aortic rupture. Once the aorta has reached a diameter of 6 cm the risk of rupture increases in proportion to the aortic diameter (Elefteriades, 2002). The 5-year cumulative risk of rupture has been estimated to be 31 % among a...

We study the heavy hitters and related sparse recovery problems in the low-failure probability regime. This regime is not well-understood, and has only been studied for non-adaptive schemes. The main previous work is on sparse recovery by Gilbert et al. (ICALP’13). We recognize an error in their analysis, improve their results, and contribute new non-adaptive and adaptive sparse recovery algori...

This study investigated the failure beliefs among Japanese junior high school students using belief scale developed by Nishimura et al. Cluster analysis was performed categorizing 280 into four distinctive clusters: “high fearfulness group” with toward failure, “failure amicable low towards and utilization-possibility of “average that showed consistently average scores over two subscales, indif...