PURPOSE Estrogen is known to promote angiogenesis in gonads. The presence of estrogen receptors in the vascular endothelium of organs other than gonads has been reported. The goal of this study was to determine whether estrogen promotes the proliferation of retinal microvascular endothelial cells and to explore the mechanism of it. METHODS DNA was quantitated using primary cultures of bovine ...

To determine if estrogen upregulates osmotic secretion of arginine vasopressin (AVP) and alters body water balance, we infused hypertonic (3% NaCl) saline in 6 women (68 ± 3 yr) after 14 days of 17β-estradiol (transdermal patch, ∼0.1 mg/day, E2) and placebo (control) administration. Hypertonic saline was infused at 0.1 ml ⋅ kg-1 ⋅ min-1for 120 min, and after a 30-min equilibration period, the s...

Among the estrogens that are biosynthesized in the human body, 17β-estradiol (estradiol or E2) is the most common and the best estrogen for neuroprotection in animal models of the central nervous system (CNS) injuries such as spinal cord injury (SCI), traumatic brain injury (TBI), and ischemic brain injury (IBI). These CNS injuries are not only serious health problems, but also enormous economi...

Tamoxifen (TAM), a non-steroidal antiestrogen, has revolutionized female breast cancer treatment. The mechanism involves is to compete with 17β-estradiol (E2) at the receptor site and blocking promotional role of E2 in cancer. Tam pioneering medicine because its widespread usage treatment chemoprevention, as well research into novel selective estrogen modulators (SERMs). In vast majority patien...

In the present study, we tested whether 17beta-estradiol (E2)-induced PRL sensitivity to somatostatin-14 (SRIF) involves selective up-regulation of discrete somatostatin receptor subtypes (ssts) in primary cultures of female rat pituitary cells. The efficacy of the endogenous peptide SRIF to inhibit GH and PRL secretion and cAMP accumulation was compared with those of octreotide (OCT), BIM-2305...

The slow Ca2+-activated K+ current (sIAHP) was recorded in CA1 pyramidal neurons in hippocampal slices obtained from ovariectomized (OVX) or sham OVX (control) female rats. The sIAHP was significantly larger in cells from OVX rats than in cells from control rats. Superfusion with 5-100 nm 17beta-estradiol (E2) caused a progressive decrease in the sIAHP in cells from OVX rats but not in cells fr...

This study focused on hepatosomatic and gonadosomatic index and levels of plasma 17β-estradiol (E2), vitellogenin (Vtg) and total protein and determined the localization of Vtg in the liver during vitellogenesis in female Chalcalburnus tarichi, an endemic cyprinid species living in the Lake Van, Turkey. The levels of plasma E2, Vtg and total protein in female fish increased during vitellogenesi...

Wastewater treatment plant effluents contain a variety of endocrine disrupting chemicals (EDCs), including with estrogenic activity such as 17β-estradiol (E2), 17α-ethinyl estradiol (EE2), and nonylphenols. These substances can affect both behavior physiology in vertebrate animals. To explore the presence effects these EDCs natural setting, juvenile adult male fathead minnows, Pimephales promel...

The binding of 3H-estradiol-17 beta(beta-D-glucuronide) (3H-E2 17G), a cholestatic organic anion, was examined in rat liver plasma membranes, and two saturable, specific binding sites were identified. The binding parameters are Kd1 = 3.9 X 10(-7) M, Bmax1 = 69 pmol/mg of protein; Kd2 = 4.90 X 10(-6) M, Bmax2 = 495 pmol/mg of protein according to Scatchard analysis of equilibrium experiments. Ki...