BACKGROUND Most patients with cystic fibrosis (CF) have a DeltaF508 mutation resulting in abnormal retention of mutant gene protein (DeltaF508-CFTR) within the cell. This study was undertaken to investigate DeltaF508-CFTR trafficking in native cells from patients with CF with the aim of discovering pharmacological agents that can move DeltaF508-CFTR to its correct location in the apical cell me...

This study aimed to overcome the researchers' extreme attention to essentially qualitative methods in research on language learners' imagined communities and move towards quantification in order to achieve a more tangible image of this construct. To do so, the present researchers followed three main phases. First, a hypothesized model of language learners' imagined communities with eight compon...

G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms that tune their response to external stimuli. Modulation of their plasma membrane density, via trafficking between subcellular compartments, constitutes an important process in this context. Substantial information has been accumulated on cellular pathways that remove GPCRs from the cell surface for subsequent d...

BACKGROUND It has been demonstrated that long-term exposure to cocaine leads to plastic changes in the brain that contribute to the manifestation of addictive behaviors. While attention has mostly focused on the meso-cortico-limbic pathway, the hippocampus seems to play a role in the craving induced by cues in drug addicts, in particular in cue- and drug-induced reinstatement of cocaine seeking...

Статья посвящена вопросам обучения английской терминологии на занятиях по иностранному языку в образовательных организациях системы МВД России. Подчеркивается необходимость учета приоритетного профиля подготовки будущих полицейских. Дается обзор существующих данный момент толковых (терминологических) словарей, содержание которых составляет лексика, объединенная рамках т.н. наркотематики. Привод...

During polarized growth of pollen tubes, endomembrane trafficking and actin polymerization are two critical processes that establish membrane/wall homeostasis and maintain growth polarity. Fine-tuned interactions between these two processes are therefore necessary but poorly understood. To better understand such cross talk in the model plant Arabidopsis (Arabidopsis thaliana), we first establis...

This study examined a model of the simultaneous and interactive influence of social context, psychosocial attitudes, and individual maturity on the prediction of urban adolescent drug dealing. Five factors were found to significantly increase adolescents' opportunity for drug selling: low parental monitoring, poor neighborhood conditions, low neighborhood job opportunity, parental substance use...

REASONS GIVEN IN DEFENCE OF TESTING The reasons most frequently given for instituting random drug testing programmes are based on the argument that it is a good tool for controlling drug problems because it offers inmates a valid excuse to avoid either drug use or participation in drug trafficking, and it assists in protecting inmates' access to programmes and transfers to lower security prison...