Bovine adenovirus type 3 (BAdV3) is being used in the development of potential vehicles for gene therapy and vectored vaccine. To that end, a more comprehensive description of BAdV3 biology is essential. In this study, we focused on the role of pIX in BAdV3 virion rescue after full-length BAdV3 genome transfection. Initially, pIX deletion or initiation codon mutation abolished the production of...

A commentary on Erkki Kauhanen (in this volume), " Innovation journalism as an essential element in the new endogenous theory of growth " 1 Introduction

The application of a coupled ®nite element± element-free Galerkin (EFG) method to problems in threedimensional fracture is presented. The EFG method is based on moving least square (MLS) approximations and uses only a set of nodal points and a CAD-like description of the body to formulate the discrete model. The EFG method is coupled with the ®nite element method which allows for the use of the...

Here, we present a sub-μm multimodal approach to image essential elements in Caenorhabditis elegans. A combination of chemical imaging technologies reveals total metal concentration, chemical state and the protein to which an element is associated. This application of distinct yet complementary chemical imaging techniques provided unique insight into essential and trace elements at the subcellu...